dc.contributor.author | Abildgaard, Anders | |
dc.contributor.author | Wegener, Gregers | |
dc.contributor.author | Elfving, Betina | |
dc.contributor.author | Hokland, Marianne | |
dc.contributor.author | Lund, Sten | |
dc.date.accessioned | 2018-10-29T11:20:20Z | |
dc.date.available | 2018-10-29T11:20:20Z | |
dc.date.issued | 2018 | |
dc.identifier.citation | Abildgaard, A. et al. 2018. The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour. Archives of physiology and biochemistry, 124(4):306-312. [https://doi.org/10.1080/13813455.2017.1398262] | en_US |
dc.identifier.issn | 1381-3455 | |
dc.identifier.issn | 1744-4160 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/31571 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/13813455.2017.1398262 | |
dc.identifier.uri | https://doi.org/10.1080/13813455.2017.1398262 | |
dc.description.abstract | Context: We have previously shown that an antidepressant-like effect of probiotics in rats was associated with a higher plasma level of the microbial tryptophan metabolite indole-3-propionic acid (IPA).
Objective: We therefore wanted to study the isolated effect of IPA on behaviour and glucose metabolism in rats.
Methods: Male Sprague–Dawley rats were fed control or IPA-enriched diet for six weeks (n = 12 per group) and assessed in the elevated plus maze, open field and forced swim test. Blood glucose, metabolic hormones and the white blood cell (WBC) composition were analysed.
Results: IPA (mean intake 27.3 mg/kg/day) significantly lowered fasting blood glucose level by 0.42 mM (95% CI 0.11–0.73). Similarly, fasting plasma insulin levels and the homeostatic model assessment (HOMA) index of insulin resistance were reduced, whereas plasma metabolic hormones, behaviour and WBC composition remained unaffected by IPA.
Conclusions: Our findings highlight IPA as a promising candidate for treatment of metabolic disorders associated with insulin resistance | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor & Francis | en_US |
dc.subject | Blood glucose | en_US |
dc.subject | Insulin | en_US |
dc.subject | Depression | en_US |
dc.subject | Diabetes mellitus | en_US |
dc.subject | Xenobiotics | en_US |
dc.title | The microbial metabolite indole-3-propionic acid improves glucose metabolism in rats, but does not affect behaviour | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 22353003 - Wegener, Gregers | |