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dc.contributor.authorLewies, Angélique
dc.contributor.authorDu Plessis, Lissinda H.
dc.contributor.authorWentzel, Johannes F.
dc.identifier.citationLewies, A. et al. 2018. Antimicrobial peptides: the Achilles’ heel of antibiotic resistance? Probiotics and antimicrobial proteins, 11(2):370-381. []en_US
dc.identifier.issn1867-1314 (Online)
dc.description.abstractAntibiotic resistance is an imminent threat to the effective treatment of bacterial infections, and alternative antibiotic strategies are urgently required. The golden epoch of antibiotics is coming to an end, and the development of new therapeutic agents to combat bacterial infections should be prioritized. This article will review the potential of antimicrobial peptides (AMPs) to combat the threat of antimicrobial resistance. The modern-day antimicrobial resistance dilemma is briefly discussed followed by a review of the potential of AMPs to be used alone or in combination with current antibiotics in order to enhance antibacterial properties of antibiotics while also potentially combatting resistance. This article reiterates that many AMPs exhibit direct microbial killing activity and also play an integral role in the innate immune system. These properties make AMPs attractive alternative antimicrobial agents. Furthermore, AMPs are promising candidates to be used as adjuvants in combination with current antibiotics in order to combat antibiotic resistance. Combinations of AMPs and antibiotics are less likely to develop resistance or transmit cross-resistance. The further identification and therapeutic development of AMPs and antibiotic-AMP combinations are strongly recommendeden_US
dc.subjectAdjuvant therapyen_US
dc.subjectAntibiotic resistanceen_US
dc.subjectAntimicrobial peptidesen_US
dc.subjectInnate immunityen_US
dc.titleAntimicrobial peptides: the Achilles’ heel of antibiotic resistance?en_US
dc.contributor.researchID20577966 - Lewies, Angélique
dc.contributor.researchID11948388 - Du Plessis, Lissinda Hester
dc.contributor.researchID20134045 - Wentzel, Johannes Frederik

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