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dc.contributor.authorSchutte, Rudolph
dc.contributor.authorSchutte, Aletta E.
dc.contributor.authorVan Rooyen, Johannes M.
dc.contributor.authorHuisman, Hugo W.
dc.contributor.authorPalmer, Iolanthé M.
dc.contributor.authorFourie, Carla M.
dc.contributor.authorPéter, Szabolcs
dc.contributor.authorMalan, Leoné
dc.contributor.authorMalan, Nicolaas T.
dc.contributor.authorReimann, Manja
dc.identifier.citationSchutte, R. et al. 2008. The Von Willebrand factor as marker of vascular function in South African women. American journal of hypertention, 21:1298-1303. []en
dc.identifier.issn1941-7225 (Online)
dc.description.abstractBACKGROUND: The increasing prevalence of hypertension and vascular-related morbidity and mortality among Africans emphasizes the need to identify markers for the early detection of vascular disease. Caucasian-based studies demonstrate that the von Willebrand factor (vWf) is a useful marker of vascular dysfunction. We investigated whether associations between this marker and markers of cardiovascular function in Caucasian women are comparable with African women. METHODS: The study consisted of apparently healthy African (n = 99) and Caucasian (n = 114) women (mean age, 31.0 years), individually matched for age and body mass index. We measured blood pressure and arterial compliance noninvasively, and vWf in serum. We assessed univariate and multivariate-adjusted associations of blood pressure and arterial compliance with vWf. RESULTS: Although no ethnic difference existed for mean vWf levels, Caucasian and African women showed opposite associations of blood pressure and arterial compliance with vWf after single, partial, and multiple regression analyses. In Caucasians, after full adjustment, systolic (beta = +0.179; P < 0.05) and diastolic (beta = +0.190; P < 0.05) blood pressure correlated positively and arterial compliance negatively (beta = -0.197; P < 0.01) with vWf. Conversely, in Africans, systolic blood pressure correlated weakly, but negatively (beta = -0.168; P = 0.059) with vWf. However, this opposite tendency seemed due to the confounding influence of the depot medroxyprogesterone acetate (DMPA) contraceptive injection and, although >99% power existed, significance disappeared after excluding these subjects (beta = -0.071; P = 0.46). CONCLUSIONS: Associations of vWf with blood pressure and arterial compliance were not comparable between Caucasian and African women, suggesting that the vWf may not be a useful marker of vascular alterations in African women.
dc.publisherOxford Univ Press
dc.titleThe Von Willebrand factor as marker of vascular function in South African womenen
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID12079642 - Kruger, Iolanthé Marike

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