Bioavailable IGF-1 is beneficially associated with biomarkers of endothelial function in young healthy adults: the African-PREDICT study
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Date
Authors
Barnard, Sunelle A.
Smith, Wayne
Mels, Catharina M.C.
Botha, Shani
Schutte, Aletta E.
Journal Title
Journal ISSN
Volume Title
Publisher
Elsevier
Abstract
Low circulating levels of insulin-like growth factor-1 (IGF-1) are associated with endothelial dysfunction, subsequently leading to the development of cardiovascular disease.
Objective
To better understand the early phases of vascular deterioration in a young, healthy population, we investigated, cross-sectionally, whether biomarkers of endothelial function (intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and von Willebrand factor antigen (vWFag)) are associated with IGF-1 in a healthy study population forming part of the larger African Prospective study on the Early Detection and Identification of Cardiovascular diseases and Hypertension (African-PREDICT).
Method
We included 825 black and white men and women (aged 20–30 years) and determined IGF-1, IGF binding protein-3 (IGFBP-3), ICAM-1, VCAM-1 and vWFag from blood samples. We also measured 24-h blood pressure and health behaviours namely waist circumference, accelerometery, cotinine and gamma glutamyl transferase. We used the IGF-1/IGFBP-3 M ratio as an estimate of bioavailable IGF-1.
Results
In multivariable-adjusted regression analyses performed in the total group, VCAM-1 associated positively with IGFBP-3 (β = 0.21; p < .001) and negatively with IGF-1/IGFBP-3 (β = −0.18; p < .001). ICAM-1 showed a borderline negative association with IGF-1 (β = −0.09; p = .054) and IGF-1/IGFBP-3 (β = −0.08; p = .057). vWFag was not associated with IGF-1, IGFBP-3 or bioavailable IGF-1.
Conclusion
VCAM-1 is beneficially associated with IGF-1 in a young healthy cohort, independent of sex, ethnicity, blood pressure and health behaviours – thereby confirming the potential importance of bioavailable IGF-1 in early vascular endothelial protection
Description
Citation
Barnard, S.A. et al. 2018. Bioavailable IGF-1 is beneficially associated with biomarkers of endothelial function in young healthy adults: the African-PREDICT study. Growth hormone and IGF research, 41:28-33. [https://doi.org/10.1016/j.ghir.2018.06.002]