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dc.contributor.authorChimhashu, Tsitsi
dc.contributor.authorMalan, Linda
dc.contributor.authorBaumgartner, Jeannine
dc.contributor.authorSmuts, Cornelius M.
dc.contributor.authorVan Jaarsveld, Paul J.
dc.identifier.citationChimhashu,T. et al. 2018. Sensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese children. British journal of nutrition, 119(6):610-619. []en_US
dc.identifier.issn1475-2662 (Online)
dc.description.abstractZn status may affect fatty acid (FA) metabolism because it acts as a cofactor in FA desaturase and elongase enzymes. Zn supplementation affects the FA desaturases of Zn-deficient rats, but whether this occurs in humans is unclear. We evaluated the associations between baseline plasma Zn (PZn) concentration and plasma total phospholipid FA composition, as well as the effect of daily consumption of Zn-fortified water on FA status in Beninese children. A 20-week, double-blind randomised controlled trial was conducted in 186 school age children. The children were randomly assigned to receive a daily portion of Zn-fortified, filtered water delivering on average 2·8mg Zn/d or non-fortified filtered water. Plasma total phospholipid FA composition was determined using capillary GLC and PZn concentrations by atomic absorption spectrometry. At baseline, PZn correlated positively with dihomo-γ-linolenic acid (DGLA, r 0·182; P=0·024) and the DGLA:linoleic acid (LA) ratio (r 0·293; P<0·000), and negatively with LA (r −0·211; P=0·009) and the arachidonic acid:DGLA ratio (r −0·170; P=0·036). With the intervention, Zn fortification increased nervonic acid (B: 0·109; 95% CI 0·001, 0·218) in all children (n 186) and more so in children who were Zn-deficient (n 60) at baseline (B: 0·230; 95% CI 0·023, 0·488). In conclusion, in this study, Zn-fortified filtered water prevented the reduction of nervonic acid composition in the plasma total phospholipids of children, and this effect was stronger in Zn-deficient children. Thus, Zn status may play an important role in FA desaturation and/or elongationen_US
dc.publisherCambridge Univ Pressen_US
dc.subjectFatty aciden_US
dc.subjectPlasma zincen_US
dc.subjectZinc fortificationen_US
dc.subjectFatty acid desaturaseen_US
dc.titleSensitivity of fatty acid desaturation and elongation to plasma zinc concentration: a randomised controlled trial in Beninese childrenen_US
dc.contributor.researchID24054909 - Baumgartner, Jeannine
dc.contributor.researchID10091130 - Malan, Linda
dc.contributor.researchID20924445 - Smuts, Cornelius Mattheus

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