Now showing items 1-2 of 2

    • Discovery of catechol-O-methyltransferase inhibitors through virtual screening 

      Smit, Monique (North-West University (South Africa) , Potchefstroom Campus, 2016)
      BACKGROUND AND RATIONALE: Parkinson’s disease (PD) is a progressive neurodegenerative disease that is caused by the death of dopaminergic neurons in the substantia nigra resulting in a loss of dopamine in the striatum. ...
    • Screening of virtual libraries for monoamine oxidase inhibitors 

      Barkhuizen, Melinda (2013)
      The traditional view of drug design is that a single drug should interact with a single molecular target. As science progressed, there was an understanding that most drugs interact with more than one target and that ...