Browsing Health Sciences by Subject "Stability"

Now showing items 1-10 of 18

    • Amorphism and polymorphism of azithromycin 

      Odendaal, Roelf Willem (North-West University, 2012)
      Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ...

    • Comparative study of the topical delivery of selected female hormones 

      Bosch, Albertha Deacon (North-West University (South-Africa), 2020)
      Intrinsic skin ageing is predominantly caused by a decrease in female hormones as menopause approaches. It is suggested that topical application of female hormones may treat these ageing symptoms. Unfortunately, the ...

    • Development of a stability indicating HPLC method for the Pheroid™ delivery system 

      Van den Berg, Elaine (North-West University, 2010)
      Stability plays an important role in the development of a new drug product. High Performance Liquid Chromatography (HPLC) is considered a stability indicating method of analysis. It is widely used in the pharmaceutical ...

    • The development of an oral single dose emulgel formulation for Pheroid® technology 

      Ludick, Charlene Ethel (2014)
      Dosage forms have been developed over the years for various applications. The dosage form consists of the active drug in combination with pharmaceutical excipients. The pharmaceutical excipients solubilise, suspend, thicken, ...

    • The development of efavirenz and praziquantel amorphous solid dispersions 

      Van Aswegen, Alwyn (North-West University (South-Africa), 2019)
      Many active pharmaceutical ingredients (API) that are highly permeable, have low aqueous solubility. Such APIs are classified as Biopharmaceutics classification system (BCS) class II drugs. Efavirenz and praziquantel both ...

    • The development of paracetamol and dapsone amorphous solid dispersions 

      Nel, A. (North-West University (South-Africa), 2021)
      The development of APIs was focused on the crystalline form over the years, but as the poor solubility of new drugs increased, the focus turned to developing the amorphous form of the drug. Dapsone (DAP) is no exception, ...

    • The development of ritonavir and pyrimethamine amorphous solid dispersions 

      Denner, R. (North-West University (South-Africa), 2021)
      Poorly soluble drugs are a major problem in the pharmaceutical industry. Not only does it lead to formulation difficulties, but it also leads to poor absorption and poor bioavailability of drugs. Ritonavir (RTV) is a ...

    • Formulation and topical delivery of niosomes and proniosomes containing carnosine 

      Lundie, Martha Maria (North-West University (South Africa) , Potchefstroom Campus, 2016)
      Wiechers (2008:1-18) explains that the efficacy of a biologically active cosmetic product depends on both the intrinsic activity of the active, as well as the delivery of the active. This study aimed to deliver the ...

    • Formulation of 5–Fluorouracil for transdermal delivery 

      Vermaas, Monique (North-West University, 2010)
      Non–melanoma skin cancer (NMSC) is the most common human malignancy and it is estimated that over 1.3 million cases are diagnosed each year in the United States (Neville et al., 2007:462). There are three main types of ...

    • Formulation, in vitro release and transdermal diffusion of selected retinoids 

      Krüger, Arina (North-West University, 2010)
      Acne is a multifactorial skin disease affecting about 80 % of people aged 11 to 30. Several systemic and topical treatments are used to treat existing lesions, prevent scarring and suppress the development of new lesions. ...