Browsing Health Sciences by Subject "Schizophrenia"
Now showing items 1-9 of 9
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Behavioural, neurochemical, inflammatory and mitichondrial markers following social isolation rearing in rats before and after selected deug intervention
(North-West University, 2012)Purpose: Schizophrenia is a progressive degenerative illness that has been causally linked to mitochondrial dysfunction, oxidative stress and a pro-inflammatory state. Social isolation rearing (SIR) in rats models the ... -
Behavioural, pharmacological and neurochemical studies of social isolation rearing in rats
(North-West University, 2007)Schizophrenia affects approximately 1% of the population. Despite marked improvement in drug treatment, 20% of patients remain treatment resistant while motor side effects hamper compliance and outcome. A better understanding ... -
Bio-behavioral characterisation of a selective α2C-receptor antagonist in animal models of schizophrenia and depression
(North-West University (South Africa) , Potchefstroom Campus, 2016)Purpose: Schizophrenia and depression are neuropsychiatric disorders characterised by affective and cognitive dysfunction and are associated with altered monoaminergic and neurotrophic function. Social isolation rearing ... -
Clozapine usage in a public sector psychiatric hospital in the Nelson Mandela Metropole
(2013)About 30.00% of schizophrenic patients fail to respond to conventional antipsychotics. Clozapine shows superior efficacy, for both the positive and negative symptoms of schizophrenia, over conventional antipsychotics. The ... -
Evaluation of selected dye compounds as inhibitors of enzymes, relevant to neurological disorders
(North-West University (South-Africa), 2021)Neurological disorders such as Alzheimer’s disease, Parkinson’s disease and schizophrenia are disorders that affect a large part of the population, especially the elderly. The cause of these disorders is still not completely ... -
Factors associated with prescribing and dispensing of schizophrenia treatment in the private health sector of South Africa
(North-West University (South Africa) , Potchefstroom Campus, 2015)The aim of this study was to determine the prevalence, medicine prescribing patterns and maximum potential savings through generic substitution in direct treatment costs associated with schizophrenia in the private health ... -
In silico screening, synthesis and in vitro determination of the biological activities of D-amino acid oxidase inhibitors
(North-West University (South-Africa), 2022)Schizophrenia is a mental disorder with many clinical and therapeutic challenges. Current therapy is based on outdated pathological theories while most antipschycotic drugs have a significant side effect profile. New ... -
Studies on Garcinia mangostana Linn as a therapeutic intervention in an immune-inflammatory model of schizophrenia
(North-West University, 2018)Schizophrenia is a life-long psychiatric disorder affecting 0.5-1% of the global population. This illness typically presents with severely debilitating clinical features in late adolescence, including positive, negative ... -
Studies on N-acetyl cysteine as a therapeutic intervention in methamphetamine-associated bio-behavioural changes in an immune-inflammatory model
(2015)Purpose: Schizophrenia is a severe illness, affecting 0.5-1% of the world population. The clinical manifestation of schizophrenia is characterized by three distinct categories of symptoms, namely positive, negative and ...
