Browsing Health Sciences by Subject "Roxithromycin"
Now showing items 1-7 of 7
-
The effect of solid-state forms on the topical delivery of roxithromycin
(2015)The skin is a very accessible and convenient route of administration for topical and systemic drugs (Williams, 2003:1). The only problem most formulators face is overcoming the barrier function of the stratum corneum, which ... -
Formulation of an emulgel for topical delivery of roxithromycin
(North-West University (South-Africa), 2020)The aim of this study was to establish whether liposomal or niosomal vesicle systems containing roxithromycin could be developed further into semi-solid formulations (emulgels) for topical delivery of the active pharmaceutical ... -
Influence of particle size on solubility of active pharmaceutical ingredients
(North-West University, 2012)The aqueous solubility of an active pharmaceutical ingredient (API) is an important property that requires evaluation during early development and prior to formulation of the final product. With general, experimental, ... -
Investigation of the stabilising effects of niosomes on the amorphous forms of roxithromycin
(North-West University (South Africa), Potchefstroom Campus, 2018)The first aim of this research study was to determine the effect of the excipients used in the typical niosome preparation on the solid-state nature of three solid-state forms of roxithromycin. The second aim was to ascertain ... -
The physico-chemical properties and recrystallisation kinetics of selected amorphous active ingredients
(North-West University (South Africa) , Potchefstroom Campus, 2015)During the last two to three decades the application of amorphous solid-state forms within the pharmaceutical industry gained much interest. The rationale for this heightened interest is the increased aqueous solubility, ... -
Roxithromycin : a solubility and stability study
(North-West University, 2011)Roxithromycin is a semi-synthetic, macrolide antibiotic, derived from erythromycin A. It acts as a bacteriostatic drug at low concentrations and a bactericidal drug at high concentrations. It binds to the 50S subunit of ... -
Stability of amorphous forms of roxithromycin when encapsulated in liposomes
(North-West University (South-Africa), 2019)Acne vulgaris is a common chronic inflammatory disease, which affects the pilosebaceous units in the dermal layer of the skin (Krautheim & Gollnick, 2004:398; Williams et al., 2012:361). Several factors are involved during ...
