Browsing Health Sciences by Subject "Rhodamine 123"
Now showing items 1-10 of 10
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Comparison of rat and porcine jejunum as in vitro models for P–glycoprotein mediated efflux using the Sweetana–Grass diffusion method
(North-West University, 2010)Absorption of drug substances across the intestinal epithelium is a complex and dynamic process. Counter transport proteins are responsible for the efflux of specific drug molecules after they have been absorbed. One of ... -
The effect of different modulators on the transport of rhodamine 123 across rat jejunum using the sweetana-grass diffusion method
(North-West University, 2004)P-glycoprotein (Pgp), which leads to multidrug resistance in tumour cells, is an ATP-dependent secretory drug efflux pump. In the intestine, as well as at specific other epithelial and endothelial sites, P-glycoprotein ... -
The effect of selected hydroxy flavonoids on the in vitro efflux transport of rhodamine 123 using rat jejunum
(North-West University, 2005)Background: Multidrug resistance (MDR) is resistance of cancer cells to multiple classes of chemotherapeutic drugs that can be structurally unrelated. MDR involves altered membrane transport that results in a lower cell ... -
The effect of selected methoxy flavonoids on the in vitro efflux transport of rhodamine 123 using rat jejunum
(North-West University, 2005)Many orally administered drugs must overcome several barriers before reaching their target site. The first major obstacle to cross is the intestinal epithelium. Although lipophilic compounds may readily diffuse across the ... -
The effects of selected health supplements on drug intestinal epithelial permeation
(North-West University (South-Africa), 2019)With the growing popularity of health supplement usage to support and maintain a healthy body there is an increasing concern for possible drug-drug and drug-supplement interactions because health supplements are not subjected ... -
Effects of selected pharmaceutical excipients on drug permeation at different gastro-intestinal tract regions
(North-West University (South Africa) , Potchefstroom Campus, 2016)Although pharmaceutical excipients are considered pharmacologically inert, some excipients in dosage forms have shown an effect on the pharmacokinetics of certain drugs. This could be due to different mechanisms such as ... -
Evaluation of the effects of selected disintegrants on drug membrane permeation
(North-West University (South Africa) , Potchefstroom Campus, 2016)Virtually all solid dosage forms contain a disintegrating agent to help facilitate breakup, dissolution and absorption. Traditionally, excipients were thought to be pharmacologically inert, but recently, an increasing ... -
An ex vivo investigation of the potential drug permeation enhancing effects of selected pepper extracts
(North-West University (South-Africa), 2019)Although the oral route is the most preferred and convenient route of drug administration when considering the patient, certain drugs (e.g. protein and peptide drugs) are mostly administrated by means of injections. This ... -
Investigation of surfactant-drug pharmacokinetic interactions
(North-West University, 2018)The oral administration route is a non-invasive, cost-effective route that is associated with high patient compliance, especially among the elderly and children. Excipients are frequently added to the active ingredient to ... -
Pharmacokinetic interactions: the effect of herbal extracts and supplements on drug permeation
(North-West University, 2018)The surge in popularity to treat illnesses with a more holistic approach is causing growing concern due to the increasing occurrence of adverse reactions, which are the result of interactions due to the concomitant use of ...
