Browsing Health Sciences by Subject "Pyrimethamine"
Now showing items 1-7 of 7
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The development of ritonavir and pyrimethamine amorphous solid dispersions
(North-West University (South-Africa), 2021)Poorly soluble drugs are a major problem in the pharmaceutical industry. Not only does it lead to formulation difficulties, but it also leads to poor absorption and poor bioavailability of drugs. Ritonavir (RTV) is a ... -
Enhancing the solubility and in vitro permeability of pyrimethamine
(North-West University (South-Africa), 2021)ABSTRACT Malaria poses a substantial health problem, with nearly half of the world’s population susceptible to it. Malaria causes an estimated one million deaths per year. People who fall prey to malaria are also burdened ... -
International pharmacopoeia monographs : antimalarial dosage forms
(North-West University, 2010)Malaria is a disease affecting millions of people in 109 malarious countries and territories, causing approximately one million deaths annually. In 2004 one of the parasites causing human malaria, Plasmodium falciparum, ... -
Investigation of solubility and permeability of sulfadoxine and pyrimethamine mixtures
(North-West University (South Africa) , Potchefstroom Campus, 2017)Sulfadoxine and pyrimethamine are commercially available in a fixed dose combination (FDC) product, which is used as prophylaxis against malaria. These drugs are still on the World Health Organization’s (WHO) essential ... -
Quality and safety implications of efavirenz and pyrimethamine crystal modifications
(2014)This study focused on two active pharmaceutical ingredients (APIs) that are used to treat two of the most notorious diseases in Africa, i.e. human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) and ... -
Solubility and dissolution testing of selected sulfadoxine/pyrimethamine mixtures
(North-West University (South Africa) , Potchefstroom Campus, 2016)Although malaria is an age old disease it continues to plague mankind especially in the African regions. Pregnant women are more likely to be infected with malaria due to the hormonal changes with more severe symptoms and ... -
Solubility enhancement of selected anti-malarial drugs
(North-West University (South-Africa), 2024-05)Malaria remains a problem experienced globally, with 227 million cases being documented in 2019 by the “World Malaria Report”. Another noted statistic is the occurence of about 54.7 million pregnancies in areas of continuous ...
