Browsing Health Sciences by Subject "Permeability"
Now showing items 1-8 of 8
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Amorphism and polymorphism of azithromycin
(North-West University, 2012)Azithromycin, an azalide and member of the macrolide group, is a broad spectrum antimicrobial, representing one of the bestselling antimicrobials worldwide. It is derived from erythromycin and exhibits improved acidic ... -
Enhancing the solubility and in vitro permeability of pyrimethamine
(North-West University (South-Africa), 2021)ABSTRACT Malaria poses a substantial health problem, with nearly half of the world’s population susceptible to it. Malaria causes an estimated one million deaths per year. People who fall prey to malaria are also burdened ... -
Improvement of the pharmaceutical availability and membrane permeability of furosemide by formulation design
(North-West University (South-Africa), 2021)Furosemide is a well-known loop diuretic having weak acidic chemical properties. Furosemide belongs to the Biopharmaceutical Classification System (BCS) class IV because it has poor aqueous solubility and poor membrane ... -
The influence of buffer composition on the solubility of baclofen and sulfadoxine
(North-West University (South-Africa), 2022)The drug discovery process has developed immensely during the last couple of decades. The Biopharmaceutical Classification System (BCS) is a drug development tool that is based on correlation of solubility and membrane ... -
Investigation of solubility and permeability of sulfadoxine and pyrimethamine mixtures
(North-West University (South Africa) , Potchefstroom Campus, 2017)Sulfadoxine and pyrimethamine are commercially available in a fixed dose combination (FDC) product, which is used as prophylaxis against malaria. These drugs are still on the World Health Organization’s (WHO) essential ... -
Pheroid® technology in the transdermal delivery of selected non-steroidal anti-inflammatory drugs
(North-West University (South Africa) , Potchefstroom Campus, 2015)Drug delivery through the skin still remains an area that enjoys active research with much of the research focusing on physical or chemical methods to reversibly alter the skin’s permeability to compounds because of the ... -
Physico-chemical properties and intestinal epithelial permeation of baclofen solid-state forms
(North-West University (South-Africa). Potchefstroom Campus, 2019)Baclofen is a centrally acting muscle relaxant that acts as an agonist of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). It is primarily used to treat muscle spasticity in patients with multiple sclerosis ... -
Rifampicin raw materials complexities and approaches to address solubility and in vitro permeability
(North-West University (South-Africa), 2021)Tuberculosis is classified as a global emergency because it is taking lives at an alarming rate and developing countries with insufficient health care systems are primarily affected. Fixed dose combination drugs (FDCs) ...