Browsing Health Sciences by Subject "Methylene blue"
Now showing items 1-8 of 8
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The antidepressant properties of selected methylene blue analogues
(2014)The shortcomings of current antidepressant agents prompts the design of novel multimodal antidepressants and the identification of new antidepressant targets, especially those located at sub-cellular level. Such ... -
The development of simple HPLC methods to separate methylene blue and its metabolites
(North-West University, 2018)The possible treatment and prevention of Alzheimer’s disease (AD) is one of many clinical applications of methylene blue (MB) that has recently attracted much interest. Due to its ability to interact with various targets, ... -
The development of simple HPLC methods to separate methylene blue and its metabolites
(North-West University (South Africa), Potchefstroom Campus, 2018)The possible treatment and prevention of Alzheimer’s disease (AD) is one of many clinical applications of methylene blue (MB) that has recently attracted much interest. Due to its ability to interact with various targets, ... -
Evaluation of selected dye compounds as inhibitors of enzymes, relevant to neurological disorders
(North-West University (South-Africa), 2021)Neurological disorders such as Alzheimer’s disease, Parkinson’s disease and schizophrenia are disorders that affect a large part of the population, especially the elderly. The cause of these disorders is still not completely ... -
Evaluation of selected dye compounds as inhibitors of monoamine oxidase
(North-West University (South-Africa), 2019)Parkinson’s disease (PD) and Alzheimer’s disease (AD) are neurodegenerative diseases that significantly impact the quality of life of patients. The pathology of Parkinson’s disease is characterised by neuronal death of the ... -
Methylene blue analogues : in vitro antimicrobial activity and in silico pharmacophore modelling
(North-West University (South-Africa), 2021)Antibiotics have drastically reduced the morbidity and mortality associated with fatal infections and have made previously impossible procedures, e.g. heart surgery, possible by allowing infections to be prevented or ... -
The role of the NO-cGMP pathway as a putative target in antidepressant action
(North-West University, 2004)Depressive disorders are among the most frequent psychiatric diseases in the Western world with prevalence between 9% and 18%. Poor compliance and inappropriate antidepressant discontinuation invokes long-term morbidity, ... -
Synthesis and biological properties of synthetic methylene blue analogues
(North-West University (South Africa) , Potchefstroom Campus, 2016)Methylene blue (MB) has diverse medical applications. Among these, MB may act as an antimalarial agent and has demonstrated potential for the treatment of neurodegenerative disorders such as Alzheimer’s disease. MB also ...
