Browsing Health Sciences by Subject "Cytochrome P450"
Now showing items 1-2 of 2
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Blood levels of selective antiretroviral drugs over a period of time, in Sprague-Dawley rats
(North-West University, 2008)Selective antiretroviral (ARV) drugs are primarily metabolized by cytochrome P450 (CYP) enzymes, characteristically predisposed to variation, and are therefore primarily responsible for ARV pharmacokinetic variability and ... -
The pharmacokinetic interaction between cyclosporine and methoxsalen
(North-West University, 2003)Cyclosporine forms the cornerstone of therapy to prevent rejection after organ transplantation. However, the clinical use of the drug is compromised by a narrow therapeutic window and a wide inter- and intra-individual ...