Browsing Health Sciences by Subject "Artesunate"
Now showing items 1-6 of 6
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Artesunate - An investigation into polymorphism
(North-West University (South-Africa), 2020)Artesunate (ART) is a derivative of artemisinin and is used in the treatment of uncomplicated Plasmodium falciparum (P. falciparum) malaria. Limited and unreliable solid-state and physico-chemical data is currently available ... -
Development and evaluation of a solid oral dosage form for an artesunate and mefloquine drug combination
(2014)Malaria affects about forty percent of the world’s population. Annually more than 1.5 million fatalities due to malaria occur and parasite resistance to existing antimalarial drugs such as mefloquine has already reached ... -
Development and evaluation of an oral fixed–dose triple combination dosage form for artesunate, dapsone and proguanil
(North-West University, 2011)Malaria is a life–threatening disease caused by Plasmodium spp and causes over one million deaths annually. The complex life cycle of the malaria parasite offers several points of attack for the antimalarial drugs. The ... -
Efficacy enhancement of the antimalarial drugs, mefloquine and artesunate, with PheroidTM technology
(North-West University, 2010)Malaria is currently one of the most imperative parasitic diseases in developing countries. Artesunate has a short half-life, low aqueous solubility and resultant poor and erratic absorption upon oral administration, which ... -
Preclinical evaluation of the possible enhancement of the efficacy of anti-malarial drugs by pheroid technology
(North-West University, 2007)Malaria is currently one of the most imperative parasitic diseases of the developing world. Current effective treatment options are limited because of increasing drug resistance, treatment cost effectiveness and treatment ... -
Solubility enhancement of selected anti-malarial drugs
(North-West University (South-Africa), 2024-05)Malaria remains a problem experienced globally, with 227 million cases being documented in 2019 by the “World Malaria Report”. Another noted statistic is the occurence of about 54.7 million pregnancies in areas of continuous ...
