• Login
    View Item 
    •   NWU-IR Home
    • Electronic Theses and Dissertations (ETDs)
    • Health Sciences
    • View Item
    •   NWU-IR Home
    • Electronic Theses and Dissertations (ETDs)
    • Health Sciences
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Triglyceride values after six months of lopinavir/ritonavir therapy as an indicator for pancreatitis risk

    Thumbnail
    View/Open
    Greffrath_WP_2016.pdf (4.578Mb)
    Date
    2016
    Author
    Greffrath, Wilhelm Petrus
    Metadata
    Show full item record
    Abstract
    Pancreatitis is the inflammation of the pancreas with varying aetiology. Hypertriglyceridaemia (HTG) is known to cause pancreatitis at triglyceride (TG) values of 11.3 mmol/L and beyond. The protease inhibitors (PIs) – a class of antiretroviral drugs that form part of some triple drug regimens indicated for the treatment of infection with the human immunodeficiency virus (HIV) – are known to induce HTG. Lopinavir/ritonavir (LPV/r) is the PI combination in a single dosage form that was relevant to this study. The primary aim of this study was to investigate the risk of pancreatitis after the first six months of LPV/r therapy. The study included adult patients, treated at the Centre for Disease Control (CDC) at a public regional hospital in KwaZulu-Natal, older than the age of 18 years that were on LPV/r-based therapy (n=194). Data collected were TG values, serum (s)-amylase values and CD4 counts after the first six months of LPV/r therapy. Risk was determined by the probability of pancreatitis in the study sample. Association between the cases of pancreatitis and cases of HTG was tested by a chi square statistical test. The chi square test was also used to determine whether there is an association between gender and pancreatitis and CD4 count and pancreatitis. No cases of pancreatitis were detected in the study sample. The mean triglyceride values (standard deviation [SD]) were 1.94 mmol/L (1.30). The mean s-amylase levels (SD) were 111.00 U/L (46.38). Both TG and s-amylase mean values were notably increased and there was a clear tendency to increase for both triglyceride levels and s-amylase levels. The mean CD4 count (SD) was 364.76 cells/μL (226.85). There was a statistically significant difference between the mean TG values (SD) of males (n=50) and that of females (n=144) at 2.36 mmol/L (1.74) and 1.79 mmol/L (1.08) respectively. There is therefore negligible risk of pancreatitis after the first six months of LPV/r therapy. However, the elevated mean triglyceride values may still warrant intervention and continuous monitoring, especially for the male population
    URI
    http://hdl.handle.net/10394/25380
    Collections
    • Health Sciences [2073]

    Copyright © North-West University
    Contact Us | Send Feedback
    Theme by 
    Atmire NV
     

     

    Browse

    All of NWU-IR Communities & CollectionsBy Issue DateAuthorsTitlesSubjectsAdvisor/SupervisorThesis TypeThis CollectionBy Issue DateAuthorsTitlesSubjectsAdvisor/SupervisorThesis Type

    My Account

    LoginRegister

    Copyright © North-West University
    Contact Us | Send Feedback
    Theme by 
    Atmire NV