A dose-response crossover iodine balance study to determine iodine requirements in early infancy
Date
2016Author
Dold, Susanne
Baumgartner, Jeannine
Zimmermann, Michael B.
Davaz, Tabea
Galetti, Valeria
Metadata
Show full item recordAbstract
Background: Optimal iodine intake during infancy is critical for
brain development, but no estimated average requirement (EAR) is
available for this age group.
Objective: We measured daily iodine intake, excretion, and retention
over a range of iodine intakes in early infancy to determine the
minimum daily intake required to achieve iodine balance.
Design: In a dose-response crossover study, we randomly assigned
healthy infants (n = 11; mean 6 SD age 13 6 3 wk) to sequentially
consume over 33 d 3 infant formula milks (IFMs) containing 10.5,
19.3, and 38.5 mg I/100 kcal, respectively. Each IFM was consumed
for 11 d, consisting of a 6-d run-in period followed by a 4-d balance
period and 1 run-out day.
Results: Iodine intake (mean 6 SD: 54.6 6 8.1, 142.3 6 23.1, and
268.4 6 32.6 mg/d), excretion (55.9 6 8.6, 121.9 6 21.7, and 228.7 6
39.3 mg/d), and retention (21.6 6 8.3, 20.6 6 21.6, and 39.8 6
34.3 mg/d) differed among the low, middle, and high iodine IFM
groups (P , 0.001 for all). There was a linear relation between
daily iodine intake and both daily iodine excretion and daily iodine
retention. Zero balance (iodine intake = iodine excretion, iodine
retention = 0 mg/d) was achieved at a daily iodine intake of 70 mg
(95% CI: 60, 80 mg).
Conclusion: Our data indicate the iodine requirement in 2- to 5-moold
infants is 70 mg/d. Adding an allowance for accumulation
of thyroidal iodine stores would produce an EAR of 72 mg and
a recommended dietary allowance of 80 mg. This trial was registered
at clinicaltrials.gov as NCT02045784
Collections
- Faculty of Health Sciences [2404]
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