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dc.contributor.authorMaritz, M.
dc.contributor.authorFourie, C.M.T.
dc.contributor.authorVan Rooyen, J.M.
dc.contributor.authorHuisman, H.W.
dc.contributor.authorSchutte, A.E.
dc.date.accessioned2017-05-15T07:22:41Z
dc.date.available2017-05-15T07:22:41Z
dc.date.issued2016
dc.identifier.citationMaritz, M. et al. 2016. Carotid characteristics of Africans with five-year sustained hypertension. Cardiovascular journal of Africa, 27(4):262-269. [http://dx.doi.org/10.5830/CVJA-2016-059]
dc.identifier.issn1995–1892
dc.identifier.issn1680–0745 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/23166
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/27841914/
dc.description.abstractIntroduction: An important feature of hypertension is a reduction in large artery distensibility, which may be due to structural and functional adaptations. Black populations are particularly prone to the development of hypertension. We therefore compared the carotid characteristics between fiveyear sustained hypertensive and normotensive black South Africans, and investigated how carotid characteristics relate to cardiometabolic risk factors, inflammation, endothelial activation and health behaviours. Methods: We included HIV-free black South Africans who were either consistently hypertensive (n = 351) or normotensive (n = 241) from 2005 to 2010. We assessed carotid characteristics, including intima–media thickness (IMT), distensibility and lumen diameter with B-mode ultrasound, and calculated Young’s elastic modulus, cross-sectional wall area and beta-stiffness index. We measured the carotid dorsalis pedis pulse-wave velocity, brachial and central systolic blood pressure (cSBP) and determined metabolic, inflammatory and endothelial activation markers from blood samples. Health behaviours were reported in questionnaires. Results: The hypertensive group presented with higher brachial and central blood pressure, thicker IMT and stiffer carotid arteries (all p < 0.001). However, after adjustment for cSBP but not mean arterial pressure (MAP), all significant differences in carotid characteristics were lost. The carotid thickness measurements did not differ after adjustment for MAP. After adjustment, metabolic, inflammatory and endothelial activation markers did not differ between the two groups. Conclusion: Our results suggest that besides structural changes, functional adaptations are also involved in deterioration of the carotid wall characteristics of hypertensive black South Africans. These results highlight the importance of proper hypertension control in Africa
dc.language.isoen
dc.publisherClinics Cardive Publ Pty Ltd
dc.titleCarotid characteristics of Africans with five-year sustained hypertension
dc.typeArticle
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID22212337 - Maritz, Melissa
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus


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