dc.contributor.author | Schutte, Aletta E. | |
dc.contributor.author | Conti, Elena | |
dc.contributor.author | Mels, Catharina M.C. | |
dc.contributor.author | Smith, Wayne | |
dc.contributor.author | Kruger, Ruan | |
dc.contributor.author | Botha, Shani | |
dc.contributor.author | Huisman, Hugo W. | |
dc.date.accessioned | 2017-05-15T07:22:35Z | |
dc.date.available | 2017-05-15T07:22:35Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Schutte, A.E. et al. 2016. Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: a five-year prospective study. European journal of preventive cardiology, 23(16):1690-1699. [http://dx.doi.org/10.1177/2047487316661436] | |
dc.identifier.issn | 2047–4873 | |
dc.identifier.issn | 2047–4881 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/23154 | |
dc.identifier.uri | http://dx.doi.org/10.1177/2047487316661436 | |
dc.description.abstract | Background:
Inconsistent findings are reported on whether insulin-like growth factor-1 (IGF-1) is protective or harmful
in predicting hypertension, carotid wall thickness and mortality. We determined the five-year prognostic value of IGF-1
for these outcomes in a large Black population prone to hypertension and cardiovascular disease.
Design:
A longitudinal study as part of the PURE (Prospective Urban and Rural Epidemiology) study, North West
Province, South Africa.
Methods:
We measured IGF-1 and IGF binding protein-3 (IGFBP-3) in 1038 HIV-uninfected participants (age range
32–94 years) and assessed blood pressure, carotid intima-media thickness and mortality.
Results:
Over five years 116 deaths occurred. Baseline IGF-1 was similar in survivors and non-survivors (
p
¼
0.50), but
tended to be higher in survivors upon adjustment for IGFBP-3 and covariates (
p
¼
0.061). Normotensives and hyper-
tensives (
p
¼
0.072), and those with carotid intima-media thickness
<
0.9 mm and
0.9 mm also displayed similar baseline
IGF-1 (
p
¼
0.55). Multivariable-adjusted Cox-regression indicated high IGF-1 predicting lower risk for all-cause mortality
(hazard ratio 0.45; 0.23–0.88) and cardiovascular mortality (hazard ratio 0.26; 0.08–0.83) when also adjusting for IGFBP-
3. When including normo- and hypertensives at baseline, high IGF-1 was related to normotension at follow-up (hazard
ratio 0.68; 0.49–0.95). We found no association with carotid intima-media thickness (hazard ratio 0.59; 0.31–1.14).
Conclusion:
In a Black South African population with low socio-economic status and harmful health behaviours, we
found a protective independent association between IGF-1 and hypertension, cardiovascular and all-cause mortality, with
no association with carotid wall thickness | |
dc.language.iso | en | |
dc.publisher | Sage Publications Ltd | |
dc.subject | Insulin-like growth factor-1 | |
dc.subject | Insulin-like growth factor binding protein-3 | |
dc.subject | African | |
dc.subject | Hypertension | |
dc.subject | Carotid intima-media thickness | |
dc.subject | Atherosclerosis | |
dc.subject | Death | |
dc.subject | Longitudinal | |
dc.title | Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: a five-year prospective study | |
dc.type | Article | |
dc.contributor.researchID | 20695241 - Botha, Shani | |
dc.contributor.researchID | 10062718 - Huisman, Hugo Willem | |
dc.contributor.researchID | 20035632 - Kruger, Ruan | |
dc.contributor.researchID | 12076341 - Mels, Catharina Martha Cornelia | |
dc.contributor.researchID | 10922180 - Schutte, Aletta Elisabeth | |
dc.contributor.researchID | 22945717 - Smith, Wayne | |