NWU Institutional Repository

IGF-1 and NT-proBNP in a black and white population: the SABPA study

Loading...
Thumbnail Image

Date

Authors

Koegelenberg, Anna S.E.
Smith, Wayne
Schutte, Rudolph
Schutte, Aletta E.

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Abstract

Background Black populations exhibit lower concentrations of the cardioprotective peptide, insulin-like growth factor-1 (IGF-1), and are more prone to develop hypertensive heart disease than whites. We therefore determined whether lower IGF-1 in black individuals relates to a marker of cardiac overload and systolic dysfunction, namely N-terminal prohormone B-type natriuretic peptide (NT-proBNP). Materials and methods We included 160 black and 195 white nondiabetic South African men and women (aged 44·4 ± 9·81 years) and measured ambulatory blood pressure, NT-proBNP, IGF-1 and insulin-like growth factor-binding protein-3 (IGFBP-3). Results Although the black group presented elevated ambulatory blood pressure accompanied by lower IGF-1 compared to the white group (all P < 0·001), we found similar NT-proBNP concentrations (P = 0·72). Furthermore, in blacks we found a link between NT-proBNP and systolic blood pressure (SBP) (R2 = 0·37; β = 0·28; P < 0·001), but not with IGF-1. In the white group, NT-proBNP was inversely associated with IGF-1 (R2 = 0·39; β = −0·22; P < 0·001) after adjusting for covariates and potential confounders. As IGF-1 is attenuated in diabetes, we added the initially excluded patients with diabetes (n = 38), and the aforementioned associations remained robust. Conclusion Contrary to the white group, we found no association between NT-proBNP and IGF-1 in black adults. Our findings suggest that SBP and other factors may play a greater contributory role in cardiac pathology in blacks

Description

Citation

Koegelenberg, A.S.E. et al. 2016. IGF-1 and NT-proBNP in a black and white population: the SABPA study. European journal of clinical investigation, 46(9):795-803. [http://dx.doi.org/10.1111/eci.12663]

Endorsement

Review

Supplemented By

Referenced By