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    Methodological variables in the analysis of cell-free DNA

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    Date
    2016
    Author
    Bronkhorst, Abel Jacobus
    Aucamp, Janine
    Pretorius, Piet J.
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    Abstract
    In recent years, cell-free DNA (cfDNA) analysis has received increasing amounts of attention as a potential non-invasive screening tool for the early detection of genetic aberrations and a wide variety of diseases, especially cancer. However, except for some prenatal tests and BEAMing, a technique used to detect mutations in various genes of cancer patients, cfDNA analysis is not yet routinely applied in clinical practice. Although some confusing biological factors inherent to the in vivo setting play a key part, it is becoming increasingly clear that this struggle is mainly due to the lack of an analytical consensus, especially as regards quantitative analyses of cfDNA. In order to use quantitative analysis of cfDNA with confidence, process optimization and standardization are crucial. In this work we aim to elucidate the most confounding variables of each preanalytical step that must be considered for process optimization and equivalence of procedures
    URI
    http://hdl.handle.net/10394/21441
    https://doi.org/10.1007/978-3-319-42044-8_29
    https://link.springer.com/chapter/10.1007%2F978-3-319-42044-8_29
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    • Conference Papers - Potchefstroom Campus [712]
    • Faculty of Natural and Agricultural Sciences [4789]

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