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dc.contributor.authorBarkhuizen, M.
dc.contributor.authorVan den Hove, D.L.A.
dc.contributor.authorVles, J.S.H.
dc.contributor.authorSteinbusch, H.W.M.
dc.contributor.authorKramer, B.W.
dc.date.accessioned2017-03-15T13:32:27Z
dc.date.available2017-03-15T13:32:27Z
dc.date.issued2017
dc.identifier.citationBarkhuizen, M. et al. 2017. 25 Years of research on global asphyxia in the immature rat brain. Neuroscience and behavioral reviews, 75:166-182. [https://doi.org/10.1016/j.neubiorev.2017.01.042]en_US
dc.identifier.issn0149-7634
dc.identifier.urihttp://hdl.handle.net/10394/20840
dc.identifier.urihttps://doi.org/10.1016/j.neubiorev.2017.01.042
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0149763416304730
dc.description.abstractHypoxic-ischemic encephalopathy remains a common cause of brain damage in neonates. Preterm infants have additional complications, as prematurity by itself increases the risk of encephalopathy. Currently, therapy for this subset of asphyxiated infants is limited to supportive care. There is an urgent need for therapies in preterm infants – and for representative animal models for preclinical drug development. In 1991, a novel rodent model of global asphyxia in the preterm infant was developed in Sweden. This method was based on the induction of asphyxia during the birth processes itself by submerging pups, still in the uterine horns, in a water bath followed by C-section. This insult occurs at a time-point when the rodent brain maturity resembles the brain of a 22–32 week old human fetus. This model has developed over the past 25 years as an established model of perinatal global asphyxia in the early preterm brain. Here we summarize the knowledge gained on the short- and long-term neuropathological and behavioral effects of asphyxia on the immature central nervous systemen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectHypoxic-ischemiaen_US
dc.subjectEncephalopathyen_US
dc.subjectPreterm infanten_US
dc.subjectSubmersionen_US
dc.subjectFunctional outcomeen_US
dc.title25 Years of research on global asphyxia in the immature rat brainen_US
dc.typeArticleen_US
dc.contributor.researchID21686866 - Barkhuizen, Melinda


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