Obsessive-compulsive disorder: insights from animal models
Date
2016Author
Szechtman, Henry
Harvey, Brian H.
Ahmari, Susanne E.
Beninger, Richard J.
Eilam, David
Metadata
Show full item recordAbstract
Research with animal models of obsessive-compulsive disorder (OCD) shows the following: (1) Optogenetic studies in mice provide evidence for a plausible cause-effect relation between increased activity in cortico-basal ganglia-thalamo-cortical (CBGTC) circuits and OCD by demonstrating the induction of compulsive behavior with the experimental manipulation of the CBGTC circuit. (2) Parallel use of several animal models is a fruitful paradigm to examine the mechanisms of treatment effects of deep brain stimulation in distinct OCD endophenotypes. (3) Features of spontaneous behavior in deer mice constitute a rich platform to investigate the neurobiology of OCD, social ramifications of a compulsive phenotype, and test novel drugs. (4) Studies in animal models for psychiatric disorders comorbid with OCD suggest comorbidity may involve shared neural circuits controlling expression of compulsive behavior. (5) Analysis of compulsive behavior into its constitutive components provides evidence from an animal model for a motivational perspective on OCD. (6) Methods of behavioral analysis in an animal model translate to dissection of compulsive rituals in OCD patients, leading to diagnostic tests
URI
http://hdl.handle.net/10394/19124https://www.sciencedirect.com/science/article/pii/S0149763415303389
https://doi.org/10.1016/j.neubiorev.2016.04.019
Collections
- Faculty of Health Sciences [2376]