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dc.contributor.authorWolmarans, De Wet
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorStein, Dan J.
dc.identifier.citationWolmarans, D.W. et al. 2016. Of mice and marbles: novel perspectives on burying behavior as a screening test for psychiatric illness. Cognitive, affective and behavioral neuroscience, 16:551-560. []en_US
dc.identifier.issn1531-135X (Online)
dc.description.abstractBurying forms part of the normal behavioral routine of rodents, although its expression is species-specific. However, it has been suggested that aberrant burying behavior, of which marble-burying (MB) is an example, may represent neophobic and/or compulsive-like behavior. In the present investigation, we assessed MB in an established animal model of obsessive–compulsive disorder (OCD)—namely, spontaneous stereotypy in the deer mouse—to establish whether high (H) stereotypy is associated with neophobia and/or another compulsive endophenotype, i.e. MB, as compared to nonstereotypical (N) controls. A three-trial, one-zone MB test was performed over three consecutive evenings both before and after chronic treatment with high-dose (50 mg/kg/day) oral escitalopram. Neophobia was measured via the number of marbles buried during the first pre- and posttreatment MB trials, and compulsive-like behavior via the number of marbles buried over all pre- and posttreatment MB trials. The data from the present study support earlier findings that burying is a normal behavioral routine (inherent burying behavior, IBB) that is expressed by all deer mice, irrespective of stereotypical cohort, and is not associated with either neophobia or compulsiveness. Indeed, chronic escitalopram treatment, which is similarly effective in treating clinical anxiety and OCD, as well as in attenuating H behavior, failed to influence IBB. Although 11 % of the animals presented with a unique burying endophenotype (high burying behavior), escitalopram also failed to attenuate said behavior, necessitating further investigation as to its relevance. In conclusion, MB cannot be regarded as a measure of anxiety-like or compulsive behavior in the deer mouse model of OCDen_US
dc.subjectObsessive-compulsive disorderen_US
dc.subjectDeer mouseen_US
dc.subjectAnimal modelen_US
dc.titleOf mice and marbles: novel perspectives on burying behavior as a screening test for psychiatric illnessen_US
dc.contributor.researchID11083417 - Harvey, Brian Herbert
dc.contributor.researchID12324515 - Wolmarans, Petrus De Wet

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