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dc.contributor.authorMalan, Leoné
dc.contributor.authorHamer, Mark
dc.contributor.authorVon Känel, Roland
dc.contributor.authorHarvey, Brian H.
dc.contributor.authorSteyn, Faans
dc.contributor.authorMalan, Nico T.
dc.date.accessioned2016-10-20T13:24:18Z
dc.date.available2016-10-20T13:24:18Z
dc.date.issued2016
dc.identifier.citationMalan, L. et al. 2016. Chronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA study. Nitric oxide, 55-56:10-17. [https://doi.org/10.1016/j.niox.2016.02.008]en_US
dc.identifier.issn1089-8603
dc.identifier.issn1089-8611 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/19120
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1089860316300143
dc.identifier.urihttps://doi.org/10.1016/j.niox.2016.02.008
dc.description.abstractBackground Depression has been associated with impaired nitric oxide (NO)-mediated vasodilation and vascular dysregulation (VD). Whether depression and NO levels will disturb retinal haemodynamics is not clear. Objectives and methods Associations between the retinal vasculature, diastolic ocular perfusion pressure (DOPP) as measure of hypoperfusion, NO metabolites (NOx) and depression symptoms were assessed. Chronic VD risk markers [depression symptoms (Patient Health Questionnaire/PHQ-9 ≥ 10) and 24 h pulse pressure] were determined in a bi-ethnic cohort (n = 313; 48.6 ± 9 years; 53.9% men). At 3 year follow-up, retinal vessel calibre and retinopathy signs were quantified from digital images. Salivary NOx was obtained pre- and post-flicker light-induced provocation (FLIP). DOPP was defined as diastolic blood pressure minus intraocular pressure. Results Chronic VD risk was evident in Blacks opposed to acute risk in Whites (P < 0.05). At follow-up, retinopathy (Blacks 60.4%/Whites 39.6%), lower pre-FLIP (μM) and higher post-FLIP NOx (changes from baseline, %), arteriolar narrowing and wider venular calibre values were evident in Blacks compared to Whites, independent of confounders. A wider venular calibre, an index of stroke risk, was associated with chronic depression symptoms [cut point 248 MU: Area under the curve 0.61 (95% CI: 0.51, 0.72); 71% sensitivity; 55% specificity] as well as with hypoperfusion in the Blacks. In this group, arteriolar narrowing was associated with hypoperfusion; and attenuated arteriolar dilation with increased post-FLIP NOx responses. Conclusions Chronic depression symptoms may alter NO regulation and facilitate VD. NO-mediated vasoconstriction presumably impeded perfusion, retinal haemodynamics and –remodelling; potentiating stroke risk in Blacksen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectDepressionen_US
dc.subjectHypoperfusionen_US
dc.subjectRetina NOxen_US
dc.subjectEthnicityen_US
dc.subjectPulse pressureen_US
dc.titleChronic depression symptoms and salivary NOx are associated with retinal vascular dysregulation: the SABPA studyen_US
dc.typeArticleen_US
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID22684808 - Hamer, Mark
dc.contributor.researchID11083417 - Harvey, Brian Herbert
dc.contributor.researchID10176527 - Steyn, Hendrik Stefanus
dc.contributor.researchID25499777 - Von Känel, Roland


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