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dc.contributor.authorMels, C.M.C.
dc.contributor.authorSchutte, A.E.
dc.contributor.authorSchutte, R.
dc.contributor.authorPretorius, P.J.
dc.contributor.authorSmith, W.
dc.contributor.authorHuisman, H.W.
dc.contributor.authorVan der Westhuizen, F.H.
dc.contributor.authorFourie, C.M.T.
dc.contributor.authorVan Rooyen, J.M.
dc.contributor.authorKruger, R.
dc.contributor.authorLouw, R.
dc.contributor.authorMalan, N.T.
dc.contributor.authorMalan, L.
dc.identifier.citationMels, C.M.C. et al. 2014. 8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA study. Free radical research, 48(11):1291-1299. []en_US
dc.identifier.issn1029-2470 (Online)
dc.description.abstractVarious studies indicate a relationship between increased oxidative stress and hypertension, resulting in increased DNA damage and consequent excretion of 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodG). The aim of this study was to compare urinary 8-oxodG levels in African and Caucasian men and to investigate the association between ambulatory blood pressure (BP) and pulse pressure (PP) with 8-oxodG in these groups. We included 98 African and 92 Caucasian men in the study and determined their ambulatory BP and PP. Biochemical analyses included, urinary 8-oxodG, reactive oxygen species (ROS) (measured as serum peroxides), ferric reducing antioxidant power (FRAP), total glutathione (GSH), glutathione peroxidase (GPx) and glutathione reductase (GR) activity. The African men had significantly higher systolic (SBP) and diastolic blood pressure (DBP) (both p < 0.001). Assessment of the oxidative stress markers indicated significantly lower 8-oxodG levels (p < 0.001) in the African group. The African men also had significantly higher ROS (p = 0.002) with concomitant lower FRAP (p < 0.001), while their GSH levels (p = 0.013) and GR activity (p < 0.001) were significantly higher. Single and partial regression analyses indicated a negative association between urinary 8-oxodG levels with SBP, DBP and PP only in African men. These associations were confirmed in multiple regression analyses (SBP: R$^2$ = 0.41; β = −0.25; p = 0.002, DBP: R$^2$ = 0.30; β = −0.21; p = 0.022, PP: R$^2$ = 0.30; β = −0.19; p = 0.03). Our results revealed significantly lower urinary 8-oxodG in African men, accompanied by a negative association with BP and PP. We propose that this may indicate a dose-response relationship in which increased oxidative stress may play a central role in the up-regulation of antioxidant defence and DNA repair mechanismsen_US
dc.publisherTaylor & Francisen_US
dc.subject8-Oxo-7, 8-dihydro-2’-deoxyguanosineen_US
dc.subjectAmbulatory blood pressureen_US
dc.subjectReactive oxygen speciesen_US
dc.title8-Oxo-7,8-dihydro-2’-deoxyguanosine, reactive oxygen species and ambulatory blood pressure in African and Caucasian men: the SABPA studyen_US
dc.contributor.researchID12076341 - Mels, Catharina Martha Cornelia
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID10176705 - Pretorius, Petrus Jacobus
dc.contributor.researchID22945717 - Smith, Wayne
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID10213503 - Van der Westhuizen, Francois Hendrikus
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID20035632 - Kruger, Ruan
dc.contributor.researchID10986707 - Louw, Roan
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné

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