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dc.contributor.authorJoubert, Ruan
dc.contributor.authorSteyn, Johan Dewald
dc.contributor.authorSteenekamp, Jan Harm
dc.contributor.authorDu Preez, Jan Lourens
dc.contributor.authorHamman, Josias Hendrik
dc.contributor.authorHeystek, Hendrik Jacobus
dc.date.accessioned2016-09-26T13:16:35Z
dc.date.available2016-09-26T13:16:35Z
dc.date.issued2016
dc.identifier.citationJoubert, R. et al. 2016. In vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into consideration. Expert opinion on drug delivery, 14(2):179-187. [https://doi.org/10.1080/17425247.2016.1211639]en_US
dc.identifier.issn1742-5247
dc.identifier.issn1744-7593 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/18880
dc.identifier.urihttps://doi.org/10.1080/17425247.2016.1211639
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/17425247.2016.1211639
dc.description.abstractIntroduction: The assessment of intestinal membrane permeability properties of new chemical entities is a crucial step in the drug discovery and development process and a variety of in vitro models, methods and techniques are available to estimate the extent of oral drug absorption in humans. However, variations in certain physiological and physico-chemical factors are often not reflected in the results and the complex dynamic interplay between these factors is sometimes oversimplified with in vitro models. Areas covered: In vitro models to evaluate drug pharmacokinetics are briefly outlined, while both physiological and physico-chemical factors that may have an influence on these techniques are critically reviewed. The shortcomings identified for some of the in vitro techniques are discussed in conjunction with novel ways to improve and thereby overcome some challenges. Expert opinion: Although conventional in vitro methods and theories are used as basic guidelines to predict drug absorption, critical evaluations have identified some shortcomings. Advancements in technology have made it possible to investigate and understand the role of physiological and physico-chemical factors in drug delivery more clearly, which can be used to improve and refine the techniques to more closely mimic the in vivo environmenten_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectIn vitro modelen_US
dc.subjectDrug permeationen_US
dc.subjectPhysiological factorsen_US
dc.subjectPhysico-chemical factorsen_US
dc.subjectPharmacokineticsen_US
dc.titleIn vitro oral drug permeation models: the importance of taking physiological and physico-chemical factors into considerationen_US
dc.typeArticleen_US
dc.contributor.researchID20712731 - Joubert, Ruan
dc.contributor.researchID12297305 - Steyn, Johan Dewald
dc.contributor.researchID10096078 - Steenekamp, Jan Harm
dc.contributor.researchID10060510 - Du Preez, Jan Lourens
dc.contributor.researchID10081097 - Hamman, Josias Hendrik
dc.contributor.researchID13037102 - Heystek, Hendrik Jacobus


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