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dc.contributor.authorScheepers, Jacobus De Wet
dc.contributor.authorMalan, Leoné
dc.contributor.authorDe Kock, Andrea
dc.contributor.authorMalan, Nicolaas Theodor
dc.contributor.authorCockeran, Marike
dc.contributor.authorVon Känel, Roland
dc.identifier.citationScheepers, J.D.W. et al. 2015. Ethnic disparity in defensive coping endothelial responses: the SABPA study. Physiology & behavior, 147:306-312. []en_US
dc.description.abstractObjectives: Defensive coping (DefS) in Blacks has been associated with greater cardiovascular risk than in their White counterparts. We examined associations between endothelial function mental stress responses and markers of vascular structure in a bi-ethnic cohort. Methods: We examined vascular function and structure in 368 Black (43.84 ± 8.31 years) and White Africans (44.78 ± 10.90 years). Fasting blood samples, 24 h blood pressure, left carotid intimamedia thickness of the far wall (L-CIMTf), and left carotid cross-sectional wall area (L-CSWA) values were obtained. von Willebrand factor (VWF), endothelin-1 (ET-1) and nitric oxide metabolite (NOx) responses to the Stroop mental stress test were calculated to assess endothelial function. DefS was assessed using the Coping Strategy Indicator questionnaire. Interaction between main effects was demonstrated for 283 participants with DefS scores above the mean of 26 for L-CIMTf. Results: Blunted stress responses for VWF (men 16.71% vs. 51. 10%; women 0.85% vs. 42.09%, respectively) and NOx (men − 64.52% vs. 74.89%; women − 76.16% vs. 113.29%, respectively) were evident in the DefS Blacks compared to theDefSWhites(pb0.001). ET-1 increased more in Blacks (men 150% and women 227%, pb0.001) compared to the Whites (men 61.25% and women 35.49%, pb0.001). Ambulatory pulse pressure, but not endothelial function markers, contributed to L-CIMTf (ΔR2=0.11pb0.001), and L-CSWA (ΔR2= 0.08, pb0.001) in DefS African men but not in any other group. Conclusions: Blunted stress-induced NOx and VWF responses and augmented ET-1 responses in DefS Blacks indicate endothelial dysfunction. DefS may facilitate disturbed endothelial responses and enforce vascular remodelling via compensatory increases in pulse pressure in Black men. The se observations may indicate an increased risk of cardiovascular incidents via functional and structural changes of the vasculature in DefS Blacks.en_US
dc.subjectEndothelial dysfunctionen_US
dc.subjectNitric oxideen_US
dc.subjectVon Willebrand factor vascular modellingen_US
dc.titleEthnic disparity in defensive coping endothelial responses: the SABPA studyen_US
dc.contributor.researchID21102007 - Cockeran, Marike
dc.contributor.researchID20273371 - De Kock, Andrea
dc.contributor.researchID10060871 - Malan, Leoné
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID20765274 - Scheepers, Jacobus De Wet

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