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dc.contributor.authorSaengtienchai, Aksorn
dc.contributor.authorIkenaka, Yoshinori
dc.contributor.authorDarwish, Wageh Sobhy
dc.contributor.authorNakayama, Shouta M.M.
dc.contributor.authorMizukawa, Hazuki
dc.date.accessioned2016-09-19T08:13:56Z
dc.date.available2016-09-19T08:13:56Z
dc.date.issued2015
dc.identifier.citationSaengtienchai, A. et al. 2015. Characterization and tissue distribution of conjugated metabolites of pyrene in the rat. Journal of veterinary medical science, 77(10):1261–1267. [http://jsvetsci.jp/jvms/]en_US
dc.identifier.issn0916–7250
dc.identifier.issn1347–7439 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/18821
dc.identifier.urihttp://doi.org/10.1292/jvms.14-0632
dc.identifier.urihttps://www.jstage.jst.go.jp/article/jvms/77/10/77_14-0632/_article
dc.description.abstractPyrene (PY) is a polycyclic aromatic hydrocarbon (PAH) that is often used as a biomarker for human and wildlife exposure to PAHs. As the metabolites of PAHs, similar to their parent compounds, pose public health risks, it is necessary to study their characteristics and tissue-specific distribution. The present study was performed to experimentally characterize PY metabolites and analyze the tissuespecific distribution of the conjugated metabolites after oral administration of PY to rats. PY metabolites, such as pyrenediol-disulfate (PYdiol-diS), pyrenediol-sulfate (PYdiol-S), pyrene-1-sufate (PYOS), pyrene-1-glucuronide (PYOG) and 1-hydroxypyrene (PYOH), were detected in rat urine. Although glucuronide conjugate was the predominant metabolite, the metabolite composition varied among tissues. Interestingly, the proportion of PYOH was high in the large intestine. Furthermore, PYOH was the only PY metabolite detected in feces. KEY WORDS: conjugated metabolites, glucuronidation, rat, sulfation, tissue distributionen_US
dc.language.isoenen_US
dc.publisherJapanese Society of Veterinary Scienceen_US
dc.subjectConjugated metabolitesen_US
dc.subjectglucuronidationen_US
dc.subjectraten_US
dc.subjectsulfationen_US
dc.subjecttissue distributionen_US
dc.titleCharacterization and tissue distribution of conjugated metabolites of pyrene in the raten_US
dc.typeArticleen_US
dc.contributor.researchID27878368 – Ikenaka, Yoshinri


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