Faculty of Health Sciences: Recent submissions
Now showing items 1261-1280 of 2404
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The fabrication and characterization of a PLGA nanoparticle–Pheroid® combined drug delivery system
(Springer, 2017)The combination of polymeric nanoparticles (NPs) as a core and lipid vesicles as a shell has emerged to be a robust and promising drug delivery strategy. This study explores the development of a novel combined delivery ... -
Rapid antidepressant effect of ketamine correlates with astroglial plasticity in the hippocampus
(Wiley, 2017)Background and purpose Astroglia contribute to the pathophysiology of major depression and antidepressant drugs act by modulating synaptic plasticity; therefore, the present study investigated whether the fast antidepressant ... -
Exposure to high levels of fumarate and succinate leads to apoptotic cytotoxicity and altered global DNA methylation profiles in vitro
(Elsevier, 2017)In the Krebs cycle, succinate is oxidized to fumarate by succinate dehydrogenase (SDH), followed by the conversion of fumarate to malate by fumarate hydratase (FH). In cells with defective SDH and FH, the Krebs cycle is ... -
25 Years of research on global asphyxia in the immature rat brain
(Elsevier, 2017)Hypoxic-ischemic encephalopathy remains a common cause of brain damage in neonates. Preterm infants have additional complications, as prematurity by itself increases the risk of encephalopathy. Currently, therapy for this ... -
The SeDeM expert diagram system: its performance and predictability in direct compressible formulations containing novel excipients and different types of active ingredients
(Elsevier, 2017)The SeDeM Expert Diagram System is a galenic pre-formulation system, which evaluates the suitability of excipients and active pharmaceutical ingredients (API's) for direct compression into tablets as well as predicting ... -
Carbon‐14 radiolabeling and tissue distribution evaluation of MMV390048
(Wiley, 2016)The antimalarial compound MMV390048 ([14C]-11) was labeled with carbon-14 isotope via a 3-step synthesis. It was obtained in a 15.5% radiochemical overall yield from carbon-14 labeled methyl iodide with a radiochemical ... -
In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species
(Elsevier, 2017)Ethnopharmacological relevance Aloe vera is one of the most important medicinal plants in the world with applications in the cosmetic industry and also in the tonic or health drink product market. Different parts of Aloe ... -
Long-lasting effects of fluoxetine and/or exercise augmentation on bio-behavioural markers of depression in pre-pubertal stress sensitive rats
(Elsevier, 2017)Juvenile depression is of great concern with only limited treatment currently approved. Delayed onset of action, low remission and high relapse rates, and potential long-lasting consequences further complicates treatment ... -
Topical delivery of roxithromycin solid-state forms entrapped in vesicles
(Elsevier, 2017)Recently, considerable interest developed in using newer/improved antibiotics for the treatment of Acne vulgaris. During this study, different roxithromycin solid-state forms (i.e. crystalline and amorphous) were encapsulated ... -
The centrality of the research question for locating PhD studies in the global knowledge society
(University of Stellenbosch, 2014)Although classified as a developing country, South Africa lags far behind other BRICS member countries. A cause for concern is that the number of PhD studies rather than what they contribute is often used to measure their ... -
The Caring School Leadership Questionnaire (CSLQ)
(Education Association of South Africa, 2014)The purpose of this research was to develop the Caring School Leadership Questionnaire (CSLQ) as a valid and reliable instrument to measure the extent of care being given by school leaders (principals) to teachers. The ... -
Curriculum, curriculum development, curriculum studies? Problematising theoretical ambiguities in doctoral theses in the education field
(Education Association of South Africa, 2014)Theoretical ambiguities in curriculum studies result in conceptual mayhem. Accordingly, they hinder the development of the complicated conversation on curriculum as a verb. This article aims to contribute to reconceptualizing ... -
Exploring programmes to support police officials exposed to trauma
(Unisa Press Host: Dept Social Work, UJ, 2015)As a result of the critical nature of police officers' work, it is of utmost importance that they have direct access to support. The efficacy of the present trauma intervention programmes in the South African Police Service ... -
Determining the impact of hunting trips on the hunter s quality of life
([AJHTL], 2015)The objective of this study was to investigate the impact of a hunting trip on hunters‟ quality of life (QoL) as measured by life domains. A number of life domains that are directly related to a hunting trip may affect the ... -
An assessment of the needs of police officials regarding trauma and trauma intervention programmes : a quantitative approach
(Criminological and Victimological Society of Southern Africa (CRIMSA), 2015)As a result of the critical nature of police officials' work, it is of utmost importance that they have direct access to support. The efficacy of the present trauma intervention programmes in the South African Police Service ... -
Mental Health workers' coping strategies in dealing with continuous secondary trauma
(Unisa Press Host: Dept Social Work, UJ, 2015)This study explored the coping strategies of mental health workers (MHWs) who are dealing continuously with traumatised children (younger than 18) and their families/caregivers. A convenience sample was used to recruit ... -
Caregiver-mediated therapy for an adult with visual and intellectual impairment suffering from separation anxiety
(Elsevier, 2015)Background Separation anxiety among intellectually disabled (ID) persons with comorbid visual impairment could be rooted in a weak sense of person permanence. Technology-assisted Therapy for Separation Anxiety (TTSA) ... -
The evaluation of an equine–assisted therapy programme with a group of boys in a youth care facility
(Taylor & Francis, 2015)The goal of this study was to evaluate the efficacy of an equine-assisted therapy programme aimed at improving the psychological well-being of boys in a custodial school of industry. Participants were 39 boys who live in ... -
Perception of social workers regarding life story work with children
(South African Society on the Abuse of Children (SAPSAC), 2015)The aim of this article was to explore how social workers perceived life story work. Narrative therapy was used as the theoretical framework of this study, which followed a qualitative descriptive design. Six registered ... -
A supervision tool to guide postgraduate students during research supervision
(Unisa Press Host: Dept Social Work, UJ, 2015)It is not uncommon for postgraduate students to postpone or terminate their studies due to emotional and/or academic reasons. The purpose of this research–based article is to propose a specific supervision tool ...
