Faculty of Health Sciences: Recent submissions
Now showing items 1001-1020 of 2404
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Body mass index cut-points to identify cardiometabolic risk in black South Africans
(Springer, 2017)Purpose To determine optimal body mass index (BMI) cut-points for the identification of cardiometabolic risk in black South African adults. Methods We performed a cross-sectional study of a weighted sample of healthy ... -
The association of endothelin-1 with markers of oxidative stress in a biethnic South African cohort: the SABPA study
(Springer Nature, 2017)Both endothelin-1 and oxidative stress have important roles in the development of cardiovascular diseases such as hypertension and atherosclerosis. Limited information is available on the interaction between oxidative ... -
Construct validity of the neighborhood environment walkability scale for Africa
(Wolters Kluwer, 2017)Purpose: The development of valid measures of built environments relevant for physical activity is an important step toward controlling the global epidemic of physical inactivity–related noncommunicable diseases and deaths. ... -
C6- and C7-substituted 3,4-dihydro-2(1H)-quinolinones as inhibitors of monoamine oxidase
(Thieme, 2017)Purpose Monoamine oxidase (MAO) inhibitors are considered to be useful therapeutic agents and isoform specific inhibitors are employed for the treatment of depression and Parkinson’s disease. MAO inhibitors are also under ... -
Social exclusion of older persons: a scoping review and conceptual framework
(Springer, 2017)As a concept, social exclusion has considerable potential to explain and respond to disadvantage in later life. However, in the context of ageing populations, the construct remains ambiguous. A disjointed evidence-base, ... -
A molecular analysis of the GBA gene in Caucasian South Africans with Parkinson's disease
(Wiley, 2017)Background The molecular basis of Parkinson's disease in South African population groups remains elusive. To date, substitutions in the GBA gene are the most common large-effect genetic risk factor for Parkinson's disease. ... -
Urinary sodium-to-potassium ratio: it may be SMART, but is it easy?
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Chemical composition, but not specific surface area, affects calcium retention of nanostructured calcium compounds in growing rats
(Oxford Univ Press, 2017)Background: Low dietary calcium intake and bioavailability may adversely affect bone health. Reducing the size of calcium compounds increases their specific surface area (SSA, expressed as m2/g) and may increase calcium ... -
Using MutPred derived mtDNA load scores to evaluate mtDNA variation in hypertension and diabetes in a two-population cohort: the SABPA study
(Elsevier, 2017)Mitochondrial DNA (mtDNA) variation has been implicated in many common complex diseases, but inconsistent and contradicting results are common. Here we introduce a novel mutational load hypothesis, which also considers the ... -
Effects of strength and endurance exercise order on endocrine responses to concurrent training
(Taylor & Francis, 2017)The present study examined the effect of strength and endurance training order on the endocrine milieu associated with strength development and performance during concurrent training. A randomised, between-groups design ... -
Mental toughness in South African youth: relationships with forgivingness and attitudes towards risk
(Sage, 2017)Young people are particularly vulnerable to health risk behaviors and interpersonal violence, stimulating scholars’ attention towards identifying factors that may reduce the likelihood that these actions will occur. ... -
May Measurement Month: a new joint global initiative by the International Society of Hypertension and the World Hypertension League to raise awareness of raised blood pressure
(Wolters Kluwer, 2017)Raised blood pressure is the biggest single contributing risk factor to death and the burden of disease worldwide. However, international data suggest that fewer than half of those with hypertension are aware of their ... -
The influence of pH on the in vitro permeation of rhodium through human skin
(Sage, 2017)Workers in precious metals refineries are at risk of exposure to salt compounds of the platinum group metals through inhalation, as well as through the skin. Rhodium salt permeation through the skin has previously been ... -
Predictive utility of European derived genetic variants associated with type 2 diabetes in a black South African population
(Springer, 2016)Type 2 diabetes (T2D) is postulated to have a polygenic etiology. Recently, polygenic risk scores of variants associated with T2D have been noted to be of useful in predicting risk in multiple ethnicities as opposed to ... -
Sex-difference in rapid changes of hippocampal astrocytes and serum level of BDNF one hour after ketamine treatment
(Elsevier, 2016)The prevalence of major depression among women is higher than men. Preclinical studies indicate that astrocytes directly involved in the synaptic plasticity of hippocampus and the impairment of astrocytic plasticity is ... -
N-acetyl cysteine as therapeutic intervention in a “two-hit” model of maternal inflammation and post-natal methamphetamine exposure
(Elsevier, 2016)Schizophrenia is a severe neurodegenerative, pro- gressive degenerative illness, prevalent in 0.5−1% of the world population. It is causally associated with a genetic aspect as well as early-life environmental stress. ... -
Perceptions of adolescents perinatally infected with hiv regarding the self-disclosure of their status
(Univ Stellenbosch, 2017)Most children born with perinatally acquired human immunodeficiency virus (HIV) are now maturing into adolescence. From an ecological systems perspective, this qualitative study aimed to explore and describe the perceptions ... -
The challenges and perceptions of community caregivers with regard to antiretroviral treatment adherence of patients: a phenomenological study
(Univ Stellenbosch, 2017)Although there is no cure for HIV and AIDS, antiretroviral treatment has transformed this disease into a manageable chronic illness. Relatively little is known about the experiences and psychosocial challenges that community ... -
Molecular phylogeny of the southern African endemic genus Sisyranthus (Apocynaceae: Asclepiadoideae-Ceropegieae)
(Elsevier, 2017)Sisyranthus E.Mey. species are placed in the tribe Ceropegieae, subtribe Anisotominae (Apocynaceae-Asclepiadoideae). Plants have their fertile parts hidden in the tube of the flowers, and are cryptic in both their habit ... -
Association of 25-hydroxyvitamin D and parathyroid hormone with the metabolic syndrome in black South African women
(Canadian Science Publishing, 2017)The relationship between 25 hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH) and metabolic traits appear to differ among ethnicities and may be influenced by obesity. The aim of the study was to examine the association ...
