Whey protein/polysaccharide-stabilized oil powders for topical application: release and transdermal delivery of salicylic acid from oil powders compared to redispersed powders
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Springer
Abstract
Oil-in-water (o/w) emulsions are commonly converted into solid-like powders in order to
improve their physical and chemical stabilities. The aim of this study was to investigate whether whey
protein/polysaccharide-stabilized o/w emulsions could be converted into stable oil powders by means
of freeze-drying. Moreover, during this study, the effects of pH and polymer type on release and
trans(dermal) delivery of salicylic acid, a model drug, from these oil powders were investigated and
compared to those of the respective template emulsions and redispersed oil powders. Physical
characterization of the various formulations was performed, such as droplet size analysis and oil
leakage, and relationships drawn with regards to release and trans(dermal) delivery. The experimental
outcomes revealed that the oil powders could be redispersed in water without changing the
release characteristics of salicylic acid. pH and polymer type affected the release of salicylic acid
from the oil powders, template emulsions, and redispersed powders similarly. Contrary, the transdermal
delivery from the oil powders and from their respective redispersed oil powders was differently
affected by pH and polymer type. It was hypothesized that the release had been influenced by the
electrostatic interactions between salicylic acid and emulsifiers, whereas the transdermal performance
could have been determined by the particle or aggregate sizes of the formulations
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Kotzé, M. et al. 2015. Whey protein/polysaccharide-stabilized oil powders for topical application: release and transdermal delivery of salicylic acid from oil powders compared to redispersed powders. AAPS pharmscitech, 16(4): 835-845. [https://doi.org/10.1208/s12249-014-0265-x]