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dc.contributor.authorDu Toit, Trizel
dc.contributor.authorMalan, Maides M.
dc.contributor.authorLemmer, Hendrik J.R.
dc.contributor.authorGouws, Chrisna
dc.contributor.authorAucamp, Marique E.
dc.contributor.authorBreytenbach, Wilma J.
dc.contributor.authorHamman, Josias H.
dc.identifier.citationDu Toit, T. et al. 2016. Combining chemical permeation enhancers for synergistic effects. European journal of drug metabolism and pharmacokinetics, 41(5):575-586. []en_US
dc.identifier.issn2107-0180 (Online)
dc.description.abstractCurrently, macromolecular drugs such as proteins are mainly administered by means of injections due to their low intestinal epithelial permeability and poor stability in the gastrointestinal tract. This study investigated binary combinations of chemical drug absorption enhancers to determine if synergistic drug absorption enhancement effects exist. Aloe vera, Aloe ferox and Aloe marlothii leaf gel materials, as well as with N-trimethyl chitosan chloride (TMC), were combined in different ratios and their effects on the transepithelial electrical resistance (TEER), as well as the transport of FITC-dextran across Caco-2 cell monolayers, were measured. The isobole method was applied to determine the type of interaction that exists between the absorption enhancers combinations. The TEER results showed synergism existed for the combinations between A. vera and A. marlothii, A. marlothii and A. ferox as well as A. vera and TMC. Antagonism interactions also occurred and can probably be explained by chemical reactions between the chemical permeation enhancers, such as complex formation. In terms of FITCdextran transport, synergism was found for combinations between A. vera and A. marlothii, A. marlothii and A. ferox, A. vera and TMC, A. ferox and TMC and A. marlothii and TMC, whereas antagonism was observed for A. vera and A. ferox. The combinations where synergism was obtained have the potential to be used as effective drug absorption enhancers at lower concentrations compared to the single componentsen_US
dc.description.sponsorshipNational Research Foundation of South Africaen_US
dc.subjectNegative Control Group
dc.subjectPermeation enhancer
dc.subjectAbsorption enhancer
dc.subjectBasolateral chamber
dc.titleCombining chemical permeation enhancers for synergistic effectsen_US
dc.contributor.researchID21649987 - Du Toit, Trizel
dc.contributor.researchID10187243 - Malan, Maides Maria
dc.contributor.researchID12450960 - Gouws, Chrisna
dc.contributor.researchID11927860 - Aucamp, Marique Elizabeth
dc.contributor.researchID10187081 - Breytenbach, Johanna Wilhelmina
dc.contributor.researchID10081097 - Hamman, Josias Hendrik
dc.contributor.researchID12932574 - Lemmer, Hendrik Jacobus Righard

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