dc.contributor.author | Milne, Marnus | |
dc.contributor.author | Liebenberg, Wilna | |
dc.contributor.author | Aucamp, Marique Elizabeth | |
dc.date.accessioned | 2016-07-22T10:46:00Z | |
dc.date.available | 2016-07-22T10:46:00Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | Milne, M. et al. 2016. Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study. International journal of pharmaceutics, 498:304-315.[https://doi.org/10.1016/j.ijpharm.2015.12.035] | en_US |
dc.identifier.issn | 0378-5173 | |
dc.identifier.issn | 1873-3476 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/18015 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0378517315304361 | |
dc.identifier.uri | https://doi.org/10.1016/j.ijpharm.2015.12.035 | |
dc.description.abstract | The striking impact that different preparation methods have on the characteristics of amorphous solidstate
forms has attracted considerable attention during the last two decades. The pursuit of more
extensive knowledge regarding polyamorphism therefore continues. The aim of this study was
firstly, to
investigate the influence of different preparation techniques to obtain amorphous solid-state forms for
the same active pharmaceutical ingredient, namely roxithromycin. The preparation techniques also
report on a method utilizing hot air, which although it is based on a melt intermediary step, is considered
a novel preparation method. Secondly, to conduct an in-depth investigation into any physico-chemical
differences between the resulting amorphous forms and thirdly, to bring our
findings into context with
that of previous work done, whilst simultaneously discussing a well-defined interpretation for the term
polyamorphism and propose a discernment between true polyamorphism and pseudo-polyamorphism/
atypical-polyamorphism. The preparation techniques included melt, solution, and a combination of
solution-mechanical disruption as intermediary steps. The resulting amorphous forms were investigated
using differential scanning calorimetry, X-ray powder diffraction, hot-stage microscopy, scanning
electron microscopy, and vapor sorption. Clear and significant thermodynamic differences were
determined between the four amorphous forms. It was also deduced from this study that different
preparation techniques have a mentionable impact on the morphological properties of the resulting
amorphous roxithromycin powders. Thermodynamic properties as well as the physical characteristics of
the amorphous forms greatly governed other physico-chemical properties i.e. solubility and dissolution | en_US |
dc.description.sponsorship | National Research Foundation (NRF) of South Africa(Grant
no.: TTK13020718661); Centre of Excellence for
Pharmaceutical Sciences (Pharmacen) at the North-West Univer-
sity Potchefstroom, South Africa | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Roxithromycin | en_US |
dc.subject | Amorphous | en_US |
dc.subject | Preparation method | en_US |
dc.subject | Polyamorphism | en_US |
dc.subject | Pseudo-polyamorphism | en_US |
dc.subject | Atypical polyamorphism | en_US |
dc.title | Different amorphous solid-state forms of roxithromycin: a thermodynamic and morphological study | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 24888923 - Milne, Marnus | |
dc.contributor.researchID | 10196226 - Liebenberg, Wilna | |
dc.contributor.researchID | 11927860 - Aucamp, Marique Elizabeth | |