International guidelines for the in vivo assessment of skin properties in non–clinical settings. Part 2. Transepidermal water loss and skin hydration
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Wiley
Abstract
Background: There is an emerging perspective that it is not
sufficient to just assess skin exposure to physical and chemical
stressors in workplaces, but that it is also important to assess
the condition, i.e. skin barrier function of the exposed skin at
the time of exposure. The workplace environment, representing
a non-clinical environment, can be highly variable and difficult
to control, thereby presenting unique measurement
challenges not typically encountered in clinical settings.
Methods: An expert working group convened a workshop as
part of the 5th International Conference on Occupational
and Environmental Exposure of Skin to Chemicals (OEESC)
to develop basic guidelines and best practices (based on
existing clinical guidelines, published data, and own experiences)
for the in vivo measurement of transepidermal water
loss (TEWL) and skin hydration in non-clinical settings
with specific reference to the workplace as a worst-case
scenario.
Results: Key elements of these guidelines are: (i) to minimize
or recognize, to the extent feasible, the influences of relevant
endogenous-, exogenous-, environmental- and measurement/
instrumentation-related factors; (ii) to measure TEWL with a
closed-chamber type instrument; (iii) report results as a difference
or percent change (rather than absolute values); and (iv)
accurately report any notable deviations from this guidelines.
Conclusion: It is anticipated that these guidelines will promote
consistent data reporting, which will facilitate inter-comparison
of study results
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Citation
Du Plessis, J. et al. 2013. International guidelines for the in vivo assessment of skin properties in non-clinical settings. Part 2. Transepidermal water loss and skin hydration. Skin research and technology, 19(3):265-278. [http://onlinelibrary.wiley.com/journal/10.1111/(ISSN)1600-0846]