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dc.contributor.authorBotha, J.
dc.contributor.authorDe Ridder, J.H.
dc.contributor.authorPotgieter, J.C.
dc.contributor.authorSteyn, H.S.
dc.contributor.authorMalan, L.
dc.date.accessioned2016-06-09T07:00:34Z
dc.date.available2016-06-09T07:00:34Z
dc.date.issued2013
dc.identifier.citationBotha, J. et al. 2013. Structural vascular disease in Africans: performance of ethnic-specific waist circumference cut points using logistic regression and neural network analyses: the SABPA study. Experimental and clinical endocrinology & diabetes, 121:515-520. [https://www.thieme.de/de/experimental-clinical-endocrinology-diabetes/journal-information-8796.htm]en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/17686
dc.identifier.urihttps://www.thieme-connect.de/products/ejournals/abstract/10.1055/s-0033-1351289
dc.identifier.uriDOI: 10.1055/s-0033-1351289
dc.identifier.uri
dc.description.abstractA recently proposed model for waist circumference cut points (RPWC), driven by increased blood pressure, was demonstrated in an African population. We therefore aimed to validate the RPWC by comparing the RPWC and the Joint Statement Consensus (JSC) models via Logistic Regression (LR) and Neural Networks (NN) analyses. Urban African gender groups (N=171) were stratified according to the JSC and RPWC cut point models. Ultrasound carotid intima media thickness (CIMT), blood pressure (BP) and fasting bloods (glucose, high density lipoprotein (HDL) and triglycerides) were obtained in a well-controlled setting. The RPWC male model (LR ROC AUC: 0.71, NN ROC AUC: 0.71) was practically equal to the JSC model (LR ROC AUC: 0.71, NN ROC AUC: 0.69) to predict structural vascular ­disease. Similarly, the female RPWC model (LR ROC AUC: 0.84, NN ROC AUC: 0.82) and JSC model (LR ROC AUC: 0.82, NN ROC AUC: 0.81) equally predicted CIMT as surrogate marker for structural vascular disease. Odds ratios supported validity where prediction of CIMT revealed ­clinical ­significance, well over 1, for both the JSC and RPWC models in African males and females (OR 3.75–13.98). In conclusion, the proposed RPWC model was substantially validated utilizing linear and non-linear analyses. We therefore propose ethnic-specific WC cut points (African males, ≥90 cm; -females, ≥98 cm) to predict a surrogate marker for structural vascular disease.en_US
dc.language.isoenen_US
dc.publisherThiemeen_US
dc.subjectCentral obesityen_US
dc.subjectanthropometryen_US
dc.subjectethnicityen_US
dc.subjectlogistic regressionen_US
dc.subjectneural networksen_US
dc.titleStructural vascular disease in Africans: performance of ethnic-specific waist circumference cut points using logistic regression and neural network analyses: the SABPA studyen_US
dc.typeArticleen_US
dc.contributor.researchID10067310 - De Ridder, Johannes Hendrik
dc.contributor.researchID10869085 - Potgieter, Johannes Cornelis
dc.contributor.researchID10176527 - Steyn, Hendrik Stefanus
dc.contributor.researchID10060871 - Malan, Leoné


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