| dc.contributor.author | Strydom, Schalk J. | |
| dc.contributor.author | Otto, Daniel P. | |
| dc.contributor.author | Liebenberg, Wilna | |
| dc.contributor.author | Rose, Warren E. | |
| dc.contributor.author | De Villiers, Melgardt M. | |
| dc.date.accessioned | 2016-06-08T09:59:37Z | |
| dc.date.available | 2016-06-08T09:59:37Z | |
| dc.date.issued | 2013 | |
| dc.identifier.citation | Strydom, S.J. et al. 2013. Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity. Nanomedicine: nanotechnology, biology and medicine, 9(1):85-93. [https://doi.org/10.1016/j.nano.2012.03.006] | en_US |
| dc.identifier.issn | 1549-9634 | |
| dc.identifier.uri | http://hdl.handle.net/10394/17677 | |
| dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S1549963412001700 | |
| dc.identifier.uri | https://doi.org/10.1016/j.nano.2012.03.006 | |
| dc.description.abstract | Silver sulfadiazine (AgSD) is a topical antibiotic with limited aqueous solubility. In this study, it was shown that poly(amido amine)
(PAMAM) dendrimer complexes with SD (SDZ) and silver (Ag) could be used for a bottom-up approach to synthesize highly-soluble AgSD
nanoparticles (NPs). These NPs were stabilized against crystal growth by electrostatic layer-by-layer (LBL) coating with various PAMAM
dendrimers. Additionally, AgNPs can be incorporated in the dendrimer shells that augmented AgSD release. NP formulation in a cream base
provided a topical drug-delivery platform with enhanced antibacterial properties against burn-wound infections, comprising three
nanostructures i.e., nano-AgSD, AgNPs as well as PAMAM dendrimers, in one efficient, elegant nanosystem | en_US |
| dc.language.iso | en | en_US |
| dc.publisher | Elsevier | en_US |
| dc.subject | PAMAM dendrimer | en_US |
| dc.subject | Silverantibiotic nanoparticles | en_US |
| dc.subject | Solubility | en_US |
| dc.subject | Release | en_US |
| dc.subject | Antibacterial | en_US |
| dc.title | Poly(amidoamine) dendrimer-mediated synthesis and stabilization of silver sulfonamide nanoparticles with increased antibacterial activity | en_US |
| dc.type | Article | en_US |
| dc.contributor.researchID | 10196226 - Liebenberg, Wilna | |
| dc.contributor.researchID | 11333561 - Otto, Daniel Petrus | |
| dc.contributor.researchID | 12428795 - Strydom, Schalk Johannes | |
