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dc.contributor.authorMazumder, Anisha
dc.contributor.authorDwivedi, Anupma
dc.contributor.authorFox, Lizelle T.
dc.contributor.authorBrümmer, Alicia
dc.contributor.authorDu Preez, Jan L.
dc.contributor.authorGerber, Minja
dc.contributor.authorDu Plessis, Jeanetta
dc.date.accessioned2016-06-07T06:17:18Z
dc.date.available2016-06-07T06:17:18Z
dc.date.issued2016
dc.identifier.citationMazumder, A. et al. 2016. In vitro skin permeation of sinigrin from its phytosome complex. Journal of pharmacy and pharmacology, 68(12):1577-1583. [https://doi.org/10.1111/jphp.12594]en_US
dc.identifier.issn0022-3573
dc.identifier.issn2042-7158 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/17629
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/abs/10.1111/jphp.12594
dc.identifier.urihttps://doi.org/10.1111/jphp.12594
dc.description.abstractObjectives: Sinigrin is a major glucosinolate present in plants of the Brassicaceae family. Recently sinigrin and its phytosome formulations have been investigated for its wound healing actions, by our research group. The aim of this study was to demonstrate sinigrin drug release from its phytosome complex and also to determine if the phytosome complex enhances the delivery of sinigrin into the skin when compared to free sinigrin. Methods: In vitro Franz cell diffusion studies were performed on human abdominal skin. The morphology of the phytosome complex was examined by transmission electron microscopy. The in vitro drug release was determined by using dialysis sacks. Key findings: The in vitro drug release indicated a controlled and sustained release of sinigrin from the phytosome complex. Tape stripping results showed that the sinigrin-phytosome complex (0.5155 µg/ml) statistically significantly enhanced the delivery of sinigrin into the stratum corneum-epidermis when compared to the free sinigrin (0.0730 µg/ml). Conclusions: These results suggested the possibility of utilizing sinigrin-phytosome complex, to optimally deliver sinigrin to the skin which can be further used for various skin related diseases including wound healingen_US
dc.description.sponsorshipNational Research Foundation (NRF) of South Africa (Grants no. IFRR81178 and CPRR13091742482) and the Centre of Excellence for Pharmaceutical Sciences (Pharmacen) at the North-West University, Potchefstroom Campus, South Africaen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.subjectSinigrinen_US
dc.subjectPhytosomeen_US
dc.subjectSinigrin-phytosome complexen_US
dc.subjectSkin permeationen_US
dc.subjectTape strippingen_US
dc.titleIn vitro skin permeation of sinigrin from its phytosome complexen_US
dc.typeArticleen_US
dc.contributor.researchID21205477 - Brümmer, Alicia
dc.contributor.researchID10060510 - Du Preez, Jan Lourens
dc.contributor.researchID11329025 - Gerber, Minja
dc.contributor.researchID10065318 - Du Plessis, Jeanetta
dc.contributor.researchID12815268 - Fox, Lizelle Trifena
dc.contributor.researchID25224786 - Mazumder, Anisha
dc.contributor.researchID25224735 - Dwivedi, Anupma


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