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    In vitro skin permeation of artemisone and its nano-vesicular formulations

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    Date
    2016
    Author
    Dwivedi, Anupma
    Mazumder, Anisha
    Fox, Lizelle T.
    Brümmer, Alicia
    Gerber, Minja
    Du Preez, Jan L.
    Haynes, Richard
    Du Plessis, Jeanetta
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    Abstract
    The artemisinin derivative artemisone has antitumor activity. In particular when encapsulated in solid lipid nanoparticles (SLNs) and niosomes, it is active against human melanoma A-375 cells, although such formulations have a negligible effect on human keratinocyte cells. The aim here was to determine whether these formulations could enhance the topical delivery and skin permeation of artemisone as a prelude to evaluating use of artemisone and related compounds for melanoma treatment. In vitro skin permeation studies were conducted to determine the concentration of artemisone delivered into the stratum corneum-epidermis and epidermis-dermis. Artemisone-SLNs delivered artemisone into the stratum corneum-epidermis at significantly higher concentration (62.632 mg/mL) than the artemisoneniosomes (12.792 mg/mL). Neither of the controls delivered artemisone into the stratum corneumepidermis. In the epidermis-dermis, artemisone (13.404 mg/mL) was only detected after application of the SLN formulation. Overall, the excellent topical delivery of artemisone with the SLN formulation coupled with the intrinsic activity of formulated artemisone confirms potential for use in treatment of melanoma
    URI
    http://hdl.handle.net/10394/16743
    https://www.sciencedirect.com/science/article/pii/S0378517316301466
    https://doi.org/10.1016/j.ijpharm.2016.02.041
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