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    Making antibiotic choices: formula derivation and usage in the rational selection of antibiotics in the empirical treatment of infections

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    Tropical Jnl Pharm Research-2013-Adorka.pdf (413.0Kb)
    Date
    2013
    Author
    Adorka, Matthias
    Lubbe, Martie
    Serfontein, Jan
    Allen, Kirk
    Kabwebwe, Honore Mitonga
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    Abstract
    Purpose: To develop mathematical formulae to aid the selection of antibiotics most appropriate in the empirical treatment of infections. Methods: Formulae quantifying the characteristics of antibiotics with regard to their cost and activity against associated bacterial isolates of given infections were derived from probability laws. Data from records of culture sensitivity test results were compiled and analysed to ascertain bacterial pathogen associations with infections and their sensitivities to prescribed antibiotics. Applicability of derived formulae was demonstrated in the rational selection of antibiotics most appropriate in the empirical treatment of urinary tract infections (UTIs) in selected hospitals in Lesotho. Results: Escherichia. coli, followed by Klebsiella spp, Proteus spp, non-haemolytic Streptococci, Streptococcus pyogenes and then, Pseudomonas spp were identified as the most common uropathogens at the hospitals studied. Two mathematical formulae were derived and used in quantifying activity and cost characteristics of prescribed antibiotics. Cefotaxime, followed by ciprofloxacin - were considered most appropriate for use in treating UTIs empirically among inpatients of the hospitals. Conclusion: Quantifying and using procedurally antibacterial activities and cost characteristics of antibiotics provides a suitable means of making antibiotic choices in the empirical treatment of infections
    URI
    http://hdl.handle.net/10394/16729
    https://www.ajol.info/index.php/tjpr/article/view/99913
    http://dx.doi.org/10.4314/tjpr.v12i6.24
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