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dc.contributor.authorStrydom, Schalk J.
dc.contributor.authorOtto, Daniel P.
dc.contributor.authorStieger, Nicole
dc.contributor.authorAucamp, Marique E.
dc.contributor.authorLiebenberg, Wilna
dc.date.accessioned2016-03-08T09:23:47Z
dc.date.available2016-03-08T09:23:47Z
dc.date.issued2014
dc.identifier.citationStrydom, S.J. et al. 2014. Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles. Powder technology, 256:470-476. [https://doi.org/10.1016/j.powtec.2014.01.088]en_US
dc.identifier.issn0032-5910
dc.identifier.issn1873-328X (Online)
dc.identifier.urihttp://hdl.handle.net/10394/16574
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0032591014001077
dc.identifier.urihttps://doi.org/10.1016/j.powtec.2014.01.088
dc.description.abstractA layer-by-layer (LbL) nanocoat (b25 nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin and paclitaxelwere chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic inspection of the coated particleswere used to confirmthe successful addition of each polyelectrolyte layer and the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume mean diameters below 250 nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50 nm thick) by adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled drug releaseen_US
dc.description.sponsorshipUniversity of Wisconsin (USA) ; North- West University (South Africa); AstraZenecaen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPoorly water solubleen_US
dc.subjectNanoparticleen_US
dc.subjectLayer-by-layeren_US
dc.subjectSelf-assemblyen_US
dc.subjectStabilityen_US
dc.subjectControlled releaseen_US
dc.titleSelf-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticlesen_US
dc.typeArticleen_US
dc.contributor.researchID12038156 - Stieger, Nicole
dc.contributor.researchID11927860 - Aucamp, Marique Elizabeth
dc.contributor.researchID10196226 - Liebenberg, Wilna
dc.contributor.researchID11333561 - Otto, Daniel Petrus
dc.contributor.researchID12428795 - Strydom, Schalk Johannes


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