dc.contributor.author | Strydom, Schalk J. | |
dc.contributor.author | Otto, Daniel P. | |
dc.contributor.author | Stieger, Nicole | |
dc.contributor.author | Aucamp, Marique E. | |
dc.contributor.author | Liebenberg, Wilna | |
dc.date.accessioned | 2016-03-08T09:23:47Z | |
dc.date.available | 2016-03-08T09:23:47Z | |
dc.date.issued | 2014 | |
dc.identifier.citation | Strydom, S.J. et al. 2014. Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles. Powder technology, 256:470-476. [https://doi.org/10.1016/j.powtec.2014.01.088] | en_US |
dc.identifier.issn | 0032-5910 | |
dc.identifier.issn | 1873-328X (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/16574 | |
dc.identifier.uri | https://www.sciencedirect.com/science/article/pii/S0032591014001077 | |
dc.identifier.uri | https://doi.org/10.1016/j.powtec.2014.01.088 | |
dc.description.abstract | A layer-by-layer (LbL) nanocoat (b25 nm thick) of two polyelectrolytes, chitosan and chondroitin sulfate was
self-assembled step-wise onto drug nanoparticles that were prepared by a solvent-evaporation emulsification
method using eucalyptol as the oil phase. Four poorly water-soluble model drugs, furosemide, isoxyl, rifampin
and paclitaxelwere chosen to prepare these particles. Zeta potential, particle size measurements, and microscopic
inspection of the coated particleswere used to confirmthe successful addition of each polyelectrolyte layer and
the stability of the nanoparticles. This manufacturing process produced stable drug nanoparticles with volume
mean diameters below 250 nm. Dissolution tests confirmed that although the nanocoat reduced the dissolution
of nanoparticles proportional to the coat thickness; they still dissolved much faster than commercially available
micronized powders of the drugs. In addition, increasing the layer thickness (still less than 50 nm thick) by
adding more LbL bilayers produced sustained release nanoparticles. Ultimately, the LbL nanocoating stabilized
these small particles against crystal growth and aggregation in suspension and resulted in nearly perfect controlled
drug release | en_US |
dc.description.sponsorship | University of Wisconsin (USA) ; North-
West University (South Africa); AstraZeneca | en_US |
dc.language.iso | en | en_US |
dc.publisher | Elsevier | en_US |
dc.subject | Poorly water soluble | en_US |
dc.subject | Nanoparticle | en_US |
dc.subject | Layer-by-layer | en_US |
dc.subject | Self-assembly | en_US |
dc.subject | Stability | en_US |
dc.subject | Controlled release | en_US |
dc.title | Self-assembled macromolecular nanocoatings to stabilize and control drug release from nanoparticles | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 12038156 - Stieger, Nicole | |
dc.contributor.researchID | 11927860 - Aucamp, Marique Elizabeth | |
dc.contributor.researchID | 10196226 - Liebenberg, Wilna | |
dc.contributor.researchID | 11333561 - Otto, Daniel Petrus | |
dc.contributor.researchID | 12428795 - Strydom, Schalk Johannes | |