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dc.contributor.authorStefaniak, Aleksandr B.
dc.contributor.authorDu Plessis, Johan
dc.contributor.authorEloff, Fritz
dc.contributor.authorJohn, Swen M.
dc.contributor.authorAgner, Tove
dc.contributor.authorChou, Tzu-Chieh
dc.contributor.authorNixon, Rosemary
dc.identifier.citationStefaniak, A.B. et al. 2013. International guidelines for the in vivo assessment of skin properties in non–clinical settings: part 1. pH. Skin research and technology, 19(2):59-68. []en_US
dc.identifier.issn1600-0846 (Online)
dc.description.abstractBackground: Skin surface pH is known to influence the dissolution and partitioning of chemicals and may influence exposures that lead to skin diseases. Non-clinical environments (e.g. workplaces) are highly variable, thereby presenting unique measurement challenges that are not typically encountered in clinical settings. Hence, guidelines are needed for consistent measurement of skin surface pH in environments that are difficult to control. Methods: An expert workshop was convened at the 5th International Conference on Occupational and Environmental Exposure of Skin to Chemicals to review available data on factors that could influence the determination of skin surface pH in non-clinical settings with emphasis on the workplace as a worst case scenario. Results: The key elements of the guidelines are: (i) minimize, to the extent feasible, the influences of relevant endogenous (anatomical position, skin health, time of day), exogenous (hand washing, barrier creams, soaps and detergents, occlusion), environmental (seasonality), and measurement (atmospheric conditions) factors; (ii) report pH measurements results as a difference or percent change (not absolute values) using a measure of central tendency and variability; and (iii) report notable deviations from these guidelines and other relevant factors that may influence measurements. Conclusion: Guidelines on the measurement and reporting of skin surface pH in non-clinical settings should promote consistency in data reporting, facilitate inter-comparison of study results, and aid in understanding and preventing occupational skin diseasesen_US
dc.description.sponsorshipNIOSH National Occupational Research Agenda Immune and Dermal cross-sector; Grants CMU98-S-28 and NSC 97-2314-B-039-022-MY3en_US
dc.subjectSkin surface pHen_US
dc.subjectworkplace measurementen_US
dc.subjectoccupational skin diseasesen_US
dc.subjectcontact dermatitisen_US
dc.subjectskin barrieren_US
dc.subjectskin absorptionen_US
dc.subjectstratum corneumen_US
dc.titleInternational guidelines for the in vivo assessment of skin properties in non–clinical settings: part 1. pHen_US
dc.contributor.researchID10101268 - Du Plessis, Johannes Lodewykus
dc.contributor.researchID10060790 - Eloff, Frederik Christoffel

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