dc.contributor.author | Reimann, Manja | |
dc.contributor.author | Hamer, Mark | |
dc.contributor.author | Malan, Nicolaas T. | |
dc.contributor.author | Malan, Leoné | |
dc.contributor.author | Schlaich, Markus P. | |
dc.contributor.author | Lambert, Gavin W. | |
dc.contributor.author | Ziemssen, Tjalf | |
dc.date.accessioned | 2016-01-29T07:58:53Z | |
dc.date.available | 2016-01-29T07:58:53Z | |
dc.date.issued | 2013 | |
dc.identifier.citation | Riemann, M. et al. 2013. Effects of acute and chronic stress on the L-arginine nitric oxide pathway in black and white South Africans: the sympathetic activity and ambulatory blood pressure in Africans study. Psychosomatic medicine, 75(8):751-758. [https://doi.org/10.1097/PSY.0b013e3182a3e465] | en_US |
dc.identifier.issn | 0033-3174 | |
dc.identifier.issn | 1534-7796 (Online) | |
dc.identifier.uri | http://hdl.handle.net/10394/16089 | |
dc.identifier.uri | http://journals.lww.com/psychosomaticmedicine/Abstract/2013/10000/Effects_of_Acute_and_Chronic_Stress_on_the.8.aspx | |
dc.identifier.uri | https://doi.org/10.1097/PSY.0b013e3182a3e465 | |
dc.description.abstract | OBJECTIVE:
This study investigated the impact of stress on effectors of the L-arginine/nitric oxide (NO) system including the endogenous inhibitor asymmetric dimethylarginine (ADMA).
METHODS:
Black (n = 168) and white (n = 206) South African teachers were exposed to a mental and a physical stressor for 1 minute, respectively. Serum samples for determination of l-arginine, NO metabolites, ADMA, and symmetric dimethylarginine (SDMA) were obtained at rest and during stress exposure. Perception of task stressfulness was assessed on a 7-point Likert scale, and psychological distress was estimated by the General Health Questionnaire.
RESULTS:
Black South Africans exhibited higher resting levels of NO metabolites (adjusted mean [standard error of the mean] = 11.3 [1.3] versus 3.9 [1.1] μmol/l, p < .001) but lower circulating ADMA (0.62 [0.02] versus 0.70 [0.02] μmol/l, p = .004) and SDMA (0.41 [0.01] versus 0.53 [0.01] μmol/l, p < .001) than did white South Africans. Ethnicity-by-psychological distress interaction was observed for resting levels of ADMA (p = .002), SDMA (p = .038), and L-arginine (p = .048). Ethnic differences in responses to experimental stress were evident for NO metabolites (blacks versus whites: 5.94 [1.55] versus -0.74 [1.25] μmol/l, p = .004) and SDMA (blacks versus whites: -0.02 [0.01] versus 0.02 [0.01] μmol/l, p = .004). Ethnicity-by-psychological distress interaction for stress responses was found for l-arginine/ADMA ratio (p = .027).
CONCLUSIONS:
The l-arginine/NO system is affected by psychosocial distress with higher susceptibility in black South Africans. This interaction may contribute to the higher cardiovascular disease risk in black South Africans | en_US |
dc.language.iso | en | en_US |
dc.publisher | Lippincott, Williams & Wilkins | en_US |
dc.subject | African | en_US |
dc.subject | asymmetric dimethylarginine | en_US |
dc.subject | cold pressor test | en_US |
dc.subject | distress | en_US |
dc.subject | l-arginine/nitric oxide pathway | en_US |
dc.title | Effects of acute and chronic stress on the L-arginine nitric oxide pathway in black and white South Africans: the sympathetic activity and ambulatory blood pressure in Africans study | en_US |
dc.type | Article | en_US |
dc.contributor.researchID | 22684808 - Hamer, Mark | |
dc.contributor.researchID | 10056173 - Malan, Nicolaas Theodor | |
dc.contributor.researchID | 10060871 - Malan, Leoné | |