Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro
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American Society for Microbiology
Abstract
The in vitro antimalarial activities of artemisone and artemisone entrapped in Pheroid vesicles were compared, as was their ability
to induce dormancy in Plasmodium falciparum. There was no increase in the activity of artemisone entrapped in Pheroid
vesicles against multidrug-resistant P. falciparum lines. Artemisone induced the formation of dormant ring stages similar to
dihydroartemisinin. Thus, the Pheroid delivery system neither improved the activity of artemisone nor prevented the induction
of dormant rings
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Grobler, L. et al. 2014. Assessment of the induction of dormant ring stages in Plasmodium falciparum parasites by artemisone and artemisone entrapped in Pheroid vesicles in vitro. Antimicrobial agents and chemotherapy, 58(12):7579-7582. [https://doi.org/10.1128/AAC.02707-14]