Mitochondrial plasticity of the hippocampus in a genetic rat model of depression after antidepressant treatment
Date
2013Author
Chen, Fenghua
Wegener, Gregers
Madsen, Torsten M.
Nyengaard, Jens R.
Metadata
Show full item recordAbstract
Depressive disorders and the treatment thereof have been associated
with a number of neuroplastic events, such as neurogenesis and synaptic remodeling
in discrete areas of the brain. The associations of these events in changes regarding
the energy supply have not been investigated. Here, we investigated the changes in
mitochondrial plasticity and its correlation to morphological alterations of neuroplasticity
in the hippocampus, both associated with a depressive phenotype, and after
treatment, with antidepressant imipramine. Design-based stereological methods were
used to estimate the number and volume of mitochondria in CA1 of the hippocampus
in two different strains of rats, the Sprague–Dawley (SD) and Flinders rats, which display
a genetic susceptibility to depressive behavior, the Flinders-sensitive line (FSL)
and their corresponding controls, the Flinders-resistant line (FRL). Results showed a
significantly reduced number of mitochondria in CA1, which was significantly smaller
in the untreated FSL saline group compared to the FRL group. However, the mean
volume of mitochondria was significantly larger in the FSL saline group compared to
the FRL saline group. Following treatment, the FSL imipramine group showed a significant
increase in the number of mitochondria compared to the FSL saline group.
Treatment with imipramine in the SD rats did not induce significant differences in
the number of mitochondria. Our results indicate that depression may be related to
impairments of mitochondrial plasticity in the hippocampus and antidepressant treatment
may counteract with the structural impairments. Moreover, the changes in
mitochondrial morphology and number are a consistent feature of neuroplasticity.
URI
http://hdl.handle.net/10394/14855https://onlinelibrary.wiley.com/doi/abs/10.1002/syn.21622
https://doi.org/10.1002/syn.21622
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- Faculty of Health Sciences [2377]