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dc.contributor.authorOverstreet, David H.
dc.contributor.authorWegener, Gregers
dc.date.accessioned2015-10-22T06:55:17Z
dc.date.available2015-10-22T06:55:17Z
dc.date.issued2013
dc.identifier.citationOverstreet, D.H. & Wegener, G. 2013. The Flinders sensitive line rat model of depression: 25 years and still producing. Pharmacological reviews, 65(1):143-155. [https://doi.org/10.1124/pr.111.005397]en_US
dc.identifier.issn0031-6997
dc.identifier.issn1521-0081 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/14853
dc.identifier.urihttp://pharmrev.aspetjournals.org/content/65/1/143
dc.identifier.urihttps://doi.org/10.1124/pr.111.005397
dc.description.abstractApproximately 25 years have passed since the first publication suggesting the Flinders sensitive line (FSL) rat as an animal model of depression. At least 6 years of research on these rats was completed before that seminal paper, and there has been a steady stream of publications (130+) over the years. The present review will focus on several issues not previously covered in earlier reviews, summarize the several lines of ongoing investigations, and propose a novel mechanism that accounts for a number of previously unexplained observations. A key observation in the FSL rat relates to the antidepressant (AD)-like effects of known and putative antidepressants. The FSL rat typically exhibits an AD-like effect in behavioral tests for AD-like activity following chronic (14 days) treatment, although some studies have found AD-like effects after fewer days of treatment. In other observations, exaggerated swim test immobility in the FSL rat has been found to have a maternal influence, as shown by cross-fostering studies and observations of maternal behavior; the implications of this finding are still to be determined. Ongoing or recently completed studies have been performed in the laboratories of Marko Diksic of Canada, Aleksander Mathé of Sweden, Gregers Wegener of Denmark, Brian Harvey of South Africa, Paul Pilowsky and Rod Irvine of Australia, and Gal Yadid of Israel. Jennifer Loftis of Portland, Oregon, and Lynette Daws of San Antonio, Texas, have been working with the FSL rats in the United States. A puzzling feature of the FSL rat is its sensitivity to multiple chemicals, and its greater sensitivity to a variety of drugs with different mechanisms of action. It has been recently shown that each of these drugs feeds through G protein–coupled receptors to potassium-gated channels. Thus, an abnormality in the potassium channel could underlie the depressed-like behavior of the FSL rats.en_US
dc.description.sponsorshipThis research was supported by The Danish Medical Research Council (Grant 11-107897), the Lundbeck Foundation, and Aarhus University Research Foundation (AU-IDEAS) (to G.W.).en_US
dc.language.isoenen_US
dc.publisherASPETen_US
dc.titleThe Flinders sensitive line rat model of depression: 25 years and still producingen_US
dc.typeArticleen_US
dc.contributor.researchID22353003 - Wegener, Gregers


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