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dc.contributor.authorViljoen, Joe M.
dc.contributor.authorCowley, Amé
dc.contributor.authorDu Preez, Jan
dc.contributor.authorGerber, Minja
dc.contributor.authorDu Plessis, Jeanetta
dc.date.accessioned2015-10-15T06:10:32Z
dc.date.available2015-10-15T06:10:32Z
dc.date.issued2015
dc.identifier.citationViljoen J.M. et al. 2015. Penetration enhancing effects of selected natural oils utilized in topical dosage forms. Drug development and industrial pharmacy, 41(12):2045-2054. [https://doi.org/10.3109/03639045.2015.1047847]en_US
dc.identifier.issn0363-9045
dc.identifier.issn1520-5762 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/14757
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/03639045.2015.1047847
dc.identifier.urihttps://doi.org/10.3109/03639045.2015.1047847
dc.description.abstractContext: Various natural products, including oils, have been utilized as penetration enhancers due to their “safety profiles”. These oils contain fatty acids promoting skin permeability through lipid fluidization within the stratum corneum; and might therefore be able to effectively enhance transdermal drug delivery. Objective: We investigated possible penetration enhancing properties of selected oils, utilizing flurbiprofen as marker compound in emulgel formulations. The formulations were compared to a liquid paraffin emulgel and a hydrogel to establish any significant penetration enhancing effects. Methods: Gas chromatographic analysis of the natural oils was performed at ambient temperature to determine the fatty acid composition in each selected natural oil. Franz cell diffusion studies and tape stripping methods were employed to study delivery of the marker into, and through the skin. Results: The following rank order for the emulgel flux-values was obtained: Hydrogel >>>> olive oil >> liquid paraffin >> coconut oil > grapeseed oil >> Avocado oil ≥ Crocodile oil >> Emu oil. Discussion: Results suggested that oils containing predominantly mono-unsaturated oleic acid, on average increased the flux of the marker to a larger extent than oils containing an almost even mixture of both mono- and polyunsaturated fatty acids. Oils comprising saturated fatty acids (SFAs) with alkyl chains between C12 and C14, increased the marker flux to a higher extent than oils containing C16-C18 SFAs. Effects observed for branched fatty acids, however, did not vary significantly from effects for unbranched fatty acids with the same carbon chain length. Conclusion: Natural oils possess penetration enhancing effects.en_US
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.subjectPenetration enhancersen_US
dc.subjectNatural oilsen_US
dc.subjectFatty acidsen_US
dc.subjectTransdermalen_US
dc.subjectFranz cell diffusion studiesen_US
dc.subjectTape strippingen_US
dc.titlePenetration enhancing effects of selected natural oils utilized in topical dosage formsen_US
dc.typeArticleen_US
dc.contributor.researchID11329025 - Gerber, Minja
dc.contributor.researchID10065318 - Du Plessis, Jeanetta
dc.contributor.researchID10060510 - Du Preez, Jan Lourens
dc.contributor.researchID11320036 - Viljoen, Johanna Magdalena
dc.contributor.researchID12025046 - Cowley, Amé


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