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dc.contributor.authorMels, Catharina M. C.
dc.contributor.authorSchutte, Aletta E.
dc.contributor.authorErasmus, Elardus
dc.contributor.authorHuisman, Hugo W.
dc.contributor.authorSchutte, Rudolph
dc.contributor.authorFourie, Carla M.T.
dc.contributor.authorKruger, Ruan
dc.contributor.authorVan Rooyen, Johannes M.
dc.contributor.authorSmith, Wayne
dc.contributor.authorMalan, Nicolaas T.
dc.contributor.authorMalan, Leoné
dc.date.accessioned2015-09-23T09:49:55Z
dc.date.available2015-09-23T09:49:55Z
dc.date.issued2013
dc.identifier.citationMels, C.M.C. et al. 2013. L-Carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA study. Lipids, 48(1):63-73. [https://doi.org/10.1007/s11745-012-3732-8]en_US
dc.identifier.issn0024-4201
dc.identifier.issn1558-9307 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/14606
dc.identifier.urihttps://link.springer.com/article/10.1007/s11745-012-3732-8
dc.identifier.urihttps://doi.org/10.1007/s11745-012-3732-8
dc.description.abstractThe prevalence of hypertension in sub-Saharan Africa is increasing rapidly, and treatment remains challenging. Although the use of l-carnitine in treatment has received much attention, studies reporting on physiological l-carnitine levels in hypertensives are limited. Our aim was to determine physiological levels of l-carnitine and acylcarnitines in African and Caucasian men, and to investigate associations between ambulatory blood pressure (BP) and carnitine levels. Participants included 101 African and 101 Caucasian teachers. Ambulatory BP measurements were conducted, and l-carnitine and acylcarnitine levels determined. African men showed significantly higher systolic BP (p < 0.001), diastolic BP (p < 0.001) and l-carnitine levels (p = 0.01). In both ethnic groups, partial regression analyses revealed a positive association between BP and l-carnitine, although in Caucasians it was with systolic (r = 0.20, p = 0.045), and in Africans with diastolic BP (r = 0.23, p = 0.023). After adjusting for confounders, an independent positive association between systolic (R 2 = 0.37, β = 0.12, p = 0.041) and diastolic BP (R 2 = 0.39, β = 0.14, p = 0.018) and l-carnitine and long-chain acylcarnitines (R 2 = 0.38, β = 0.17, p = 0.005 and R 2 = 0.39, β = 0.15, p = 0.011) were found, independent of ethnicity. Physiological l-carnitine levels were not only higher in Africans than in Caucasians but also above the expected reference range. Despite promising results on l-carnitine (and its short-chain derivatives) in hypertension treatment regimens, our findings paradoxically show that elevated BP is significantly associated with higher physiological l-carnitine and long-chain acylcarnitine levels.en_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.subjectAmbulatory blood pressureen_US
dc.subjectL-Carnitineen_US
dc.subjectlong-chain acylcarnitinesen_US
dc.subjectethnicityen_US
dc.subjectlipid biochemistryen_US
dc.subjectb-Oxidationen_US
dc.subjectfatty acid metabolismen_US
dc.subjectheart lipid metabolismen_US
dc.subjectnuclear receptorsen_US
dc.titleL-Carnitine and long-chain acylcarnitines are positively correlated with ambulatory blood pressure in humans: the SABPA studyen_US
dc.typeArticleen_US
dc.contributor.researchID12076341 - Mels, Catharina Martha Cornelia
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID10066136 - Erasmus, Elardus
dc.contributor.researchID10062718 - Huisman, Hugo Willem
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID10062491 - Fourie, Catharina Maria Theresia
dc.contributor.researchID20035632 - Kruger, Ruan
dc.contributor.researchID10059539 - Van Rooyen, Johannes Marthinus
dc.contributor.researchID22945717 - Smith, Wayne
dc.contributor.researchID10056173 - Malan, Nicolaas Theodor
dc.contributor.researchID10060871 - Malan, Leoné


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