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dc.contributor.authorButler, Catharina J.
dc.contributor.authorSchutte, Rudolph
dc.contributor.authorGlyn, Matthew C.
dc.contributor.authorVan der Westhuizen, Francois H.
dc.contributor.authorGona, Philimon
dc.contributor.authorSchutte, Aletta E.
dc.date.accessioned2015-09-09T10:15:25Z
dc.date.available2015-09-09T10:15:25Z
dc.date.issued2013
dc.identifier.citationButler, C.J. et al. 2013. Exploring the link between serum peroxides and angiogenesis in a bi-ethnic population from South Africa: the SAfrEIC study. Journal of the American Society of Hypertension, 7(4):267-275. [https://doi.org/10.1016/j.jash.2013.04.005]en_US
dc.identifier.issn1933-1711
dc.identifier.issn1878-7436 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/14456
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1933171113000739
dc.identifier.urihttps://doi.org/10.1016/j.jash.2013.04.005
dc.description.abstractBackground: Reactive oxygen species (ROS) play a fundamental role in angiogenesis, and in turn, angiogenic growth factors also affect ROS. Angiogenesis and ROS are intricately involved in vascular deterioration. Since black populations are known to have elevated oxidative stress and hypertension, we determined whether relationships exist between angiogenic growth factors and serum peroxides in Africans and Caucasians and evaluated the relationships with cardiovascular measurements. Methods: We measured vascular endothelial growth factor-A (VEGF), angiopoietin 2 (Ang-2), and serum peroxides in Africans (N = 262) and Caucasians (N = 364) aged 20 to 70 years. Results: Africans displayed higher blood pressure, serum peroxide levels, VEGF, and Ang-2 (all P ≤ .002) than similarly aged Caucasians (P = .44). In multivariable adjusted analyses, Ang-2 was independently associated with serum peroxides in African men (R2 = 0.31; β = 0.21; P = .014) and women (R2 = 0.09; β = 0.22; P = .025); and VEGF with serum peroxides in African men (R2 = 0.12; β = 0.24; P = .014), with no statistically significant associations in Caucasians. Cardiovascular measurements did not associate with serum peroxides or angiogenic factors in any subgroup. Conclusions: Significant independent relationships exist between angiogenic growth factors and serum peroxides only in Africans who also displayed an unfavorable cardiovascular profile when compared with Caucasians. These results suggest that interplay between ROS and angiogenesis occur in African individuals that may form part of the mechanisms involved in vascular deterioration.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectEthnicityen_US
dc.subjectBlacken_US
dc.subjectAfricanen_US
dc.subjectOxidative stressen_US
dc.subjectVascular endothelial growth factoren_US
dc.subjectAngiopoietin-2en_US
dc.subjectBlood pressureen_US
dc.titleExploring the link between serum peroxides and angiogenesis in a bi-ethnic population from South Africa: the SAfrEIC studyen_US
dc.typeArticleen_US
dc.contributor.researchID10922180 - Schutte, Aletta Elisabeth
dc.contributor.researchID12201405 - Schutte, Rudolph
dc.contributor.researchID22419853 - Glyn, Matthew Colin Patrick
dc.contributor.researchID10213503 - Van der Westhuizen, Francois Hendrikus
dc.contributor.researchID20810148 - Butler, Catharina Johanna


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