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dc.contributor.authorBooysen, L.L.I.J.
dc.contributor.authorKotzé, A.F.
dc.contributor.authorDu Plessis, L.H.
dc.contributor.authorKalombo, L.
dc.contributor.authorBrooks, E.
dc.date.accessioned2015-07-21T09:21:08Z
dc.date.available2015-07-21T09:21:08Z
dc.date.issued2013
dc.identifier.citationBooysen, L.L.I.J. et al. 2013. In vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniazid. International journal of pharmaceutics, 444:10-17. [https://doi.org/10.1016/j.ijpharm.2013.01.038]en_US
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476 (Online)
dc.identifier.urihttp://hdl.handle.net/10394/14112
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0378517313000690
dc.identifier.urihttps://doi.org/10.1016/j.ijpharm.2013.01.038
dc.description.abstractPoly-(dl-lactic-co-glycolic) acid (PLGA) nanoparticles were prepared by a double emulsion solvent evaporation spray-drying technique and coated with polyethylene glycol (PEG 1% v/v). The PLGA nanoparticles had a small size (229 ± 7.6 to 382 ± 23.9 nm), uniform size distribution and positive zeta potential (+12.45 ± 4.53 mV). In vitro/in vivo assays were performed to evaluate the pharmacokinetic (PK) and pharmacodynamic (PD) performance of these nanoparticles following nanoencapsulation of the antituberculosis drugs rifampicin (RIF) and isoniazid (INH). The results demonstrated the potential for the reduction in protein binding of these drugs by protection in the polymer core. Furthermore, in vitro efficacy was demonstrated using Mycobacterium tuberculosis (M. tb.) (strain H37Rv). Sustained drug release over seven days were observed for these drugs following once-off oral administration in mice with subsequent drug distribution of up to 10 days in the liver and lungs for RIF and INH, respectively. It was concluded by these studies combined with our previous reports that spray-dried PLGA nanoparticles demonstrate potential for the improvement of tuberculosis chemotherapy by nanoencapsulation of anti-tuberculosis drugs.en_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectPLGA nanoparticlesen_US
dc.subjectIn vitroen_US
dc.subjectIn vivoen_US
dc.subjectPharmacokineticen_US
dc.subjectPharmacodynamicen_US
dc.subjectRifampicinen_US
dc.subjectIsoniaziden_US
dc.subjectPEG coateden_US
dc.titleIn vivo/in vitro pharmacokinetic and pharmacodynamic study of spray-dried poly-(dl-lactic-co-glycolic) acid nanoparticles encapsulating rifampicin and isoniaziden_US
dc.typeArticleen_US
dc.contributor.researchID10200142 - Kotzé, Abraham Frederik
dc.contributor.researchID11948388 - Du Plessis, Lissinda Hester
dc.contributor.researchID12019798 - Booysen, Laetitia Lucretia Ismeralda Josephine


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